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DisSARMing Toll-like receptor signaling

Nature Immunology volume 7, pages 1023–1025 (2006)Cite this article

Toll-like receptor (TLR) signaling must be tightly regulated to avoid uncontrolled inflammation. A fifth Toll–interleukin 1 receptor adaptor domain, SARM, has been identified as an inhibitor of TLR3 and TLR4 signaling.

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Figure 1: SARM targets TRIF in TLR4 and TLR3 signaling.

Kim Caesar

References

  1. Liew, F.Y., Xu, D., Brint, E.K. & O'Neill, L.A.J. Nat. Rev. Immunol. 5, 446–458 (2005).

    Article  CAS  Google Scholar 

  2. Carty, M. et al. Nat. Immunol. 7, 1074–1081 (2006).

    Article  CAS  Google Scholar 

  3. Mink, M., Fogelgren, B., Olszewski, K., Maroy, P. & Csiszar, K. Genomics 74, 234–244 (2001).

    Article  CAS  Google Scholar 

  4. O'Neill, L.A.J., Fitzgerald, K.A. & Bowie, A.G. Trends Immunol. 24, 286–289 (2003).

    Article  Google Scholar 

  5. Fitzgerald, K.A. et al. J. Exp. Med. 198, 1043–1055 (2003).

    Article  CAS  Google Scholar 

  6. Fitzgerald, K.A. et al. Nature 413, 78–83 (2001).

    Article  CAS  Google Scholar 

  7. Couillault, C. et al. Nat. Immunol. 5, 488–494 (2004).

    Article  CAS  Google Scholar 

  8. Liberati, N.T. et al. Proc. Natl. Acad. Sci. USA 101, 6593–6598 (2004).

    Article  CAS  Google Scholar 

  9. Chuang, C.F. & Bargmann, C.I. Genes Dev. 19, 270–281 (2005).

    Article  CAS  Google Scholar 

  10. Kim, C.A. & Bowie, J.U. Trends Biochem. Sci. 28, 625–628 (2003).

    Article  CAS  Google Scholar 

  11. Su, X. et al. Eur. J. Immunol. 36, 199–206 (2006).

    Article  CAS  Google Scholar 

  12. Rowe, D. et al. Proc. Natl. Acad. Sci. USA 103, 6299–6304 (2006).

    Article  CAS  Google Scholar 

  13. McGettrick, A. et al. Proc. Natl. Acad. Sci. USA 103, 9196–9201 (2006).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. School of Biochemistry and Immunology, Trinity College, Dublin, Ireland

    Luke A J O'Neill

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  1. Luke A J O'Neill
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O'Neill, L. DisSARMing Toll-like receptor signaling. Nat Immunol 7, 1023–1025 (2006). https://doi.org/10.1038/ni1006-1023

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