Abstract
Ca2+ signals control a variety of lymphocyte responses, ranging from short-term cytoskeletal modifications to long-term changes in gene expression. The identification of molecules and channels that modulate Ca2+ entry into T and B lymphocytes has both provided details of the molecular events leading to immune responses and raised controversy. Here we review studies of the pathways that allow Ca2+ entry, the function of Ca2+ in the regulation of cell polarity and motility and the principles by which Ca2+-dependent transcription regulates lymphocyte function.
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Acknowledgements
We thank M. Winslow and J. Arron for critically reading the manuscript. Supported by a Stanford Graduate Fellowship (E.M.G.), Boehringer Ingelheim Fonds (K.C.-B.), the Howard Hughes Medical Institute (G.R.C.) and the National Institutes of Health (AI-60037).
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Gallo, E., Canté-Barrett, K. & Crabtree, G. Lymphocyte calcium signaling from membrane to nucleus. Nat Immunol 7, 25–32 (2006). https://doi.org/10.1038/ni1295
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DOI: https://doi.org/10.1038/ni1295
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