Nature Immunology 6, 1211 - 1212 (2005)
doi:10.1038/ni1205-1211
Pin1: a proline isomerase that makes you wheeze?Paul Anderson
Paul Anderson is in the Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA. panderson@rics.bwh.harvard.edu
The accumulation of eosinophils in lung tissue, an invariant feature of allergic asthma, requires autocrine production of the cytokine GM-CSF. New data suggest protein isomerization mediated by the enzyme Pin1 is key to the stability of GM-CSF mRNA and eosinophil survival.
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