Nature Immunology
6, 1029 - 1037 (2005)
Published online: 11 September 2005; | doi:10.1038/ni1249
Activation of bone marrow−resident memory T cells by circulating, antigen-bearing dendritic cellsLois L Cavanagh1, 5, 6, Roberto Bonasio1, 5, Irina B Mazo1, Cornelia Halin1, Guiying Cheng1, Adrianus W M van der Velden2, Annaiah Cariappa3, Catherine Chase3, Paul Russell3, Michael N Starnbach2, Pandelakis A Koni4, Shiv Pillai3, Wolfgang Weninger1, 6
& Ulrich H von Andrian11
The CBR Institute for Biomedical Research and Department of Pathology, Harvard Medical School, Boston, Massachusetts
02115, USA. 2
Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts
02115, USA. 3
Massachusetts General Hospital Cancer Center, Charlestown, Massachusetts
02129, USA. 4
Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, Georgia
30912, USA. 5
These authors contributed equally to this work. 6
Present address: The Wistar Institute, Philadelphia, Pennsylvania
19104, USA.
Correspondence should be addressed to Ulrich H von Andrian uva@cbr.med.harvard.edu Dendritic cells (DCs) carry antigen from peripheral tissues via lymphatics to lymph nodes. We report here that differentiated DCs can also travel from the periphery into the blood. Circulating DCs migrated to the spleen, liver and lung but not lymph nodes. They also homed to the bone marrow, where they were retained better than in most other tissues. Homing of DCs to the bone marrow depended on constitutively expressed vascular cell adhesion molecule 1 and endothelial selectins in bone marrow microvessels. Two-photon intravital microscopy in bone marrow cavities showed that DCs formed stable antigen-dependent contacts with bone marrow−resident central memory T cells. Moreover, using this previously unknown migratory pathway, antigen-pulsed DCs were able to trigger central memory T cell−mediated recall responses in the bone marrow.
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