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The last molecular fortress in leukocyte trans-endothelial migration

Leukocyte arrest on inflamed endothelium constitutes only the first phase of their recruitment into the tissues. New data points to the roles played by JAM-1 and CD99 in leukocyte passage through the barrier posed by the vascular endothelium during inflammatory responses.

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Figure 1: New molecular mechanisms in leukocyte transendothelial migration.

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Aurrand-Lions, M., Johnson-Leger, C. & Imhof, B. The last molecular fortress in leukocyte trans-endothelial migration. Nat Immunol 3, 116–118 (2002). https://doi.org/10.1038/ni0202-116

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