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The origins of the adaptive immune system: whatever next?

The discovery of a V-like Ig multigene family in the protochordate amphioxus provides new insights into the evolution of the adaptive immune response.

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Photo credit: C. Andrews and J. Cannon.

References

  1. Cannon, J.P., Haire, R.N. & Litman, G.L. Nature Immunol. 3, 1200–1207 (2002).

    Article  CAS  Google Scholar 

  2. Litman, G.W., Anderson, M.K. & Rast, J.P. Annu. Rev. Immunol. 17, 109–147 (1999).

    Article  CAS  Google Scholar 

  3. Flajnik, M.F. & Kasahara, M. Immunity 15, 351–362 (2001).

    Article  CAS  Google Scholar 

  4. Barclay, A.N. et al. The Leucocyte Antigen Facts Book (Academic Press, San Diego, CA, 1997)

    Google Scholar 

  5. Tonegawa, S. Nature 302, 575–581 (1983).

    Article  CAS  Google Scholar 

  6. Harpaz, Y. & Chothia, C. J. Mol. Biol. 238, 528–539 (1994).

    Article  CAS  Google Scholar 

  7. Teichmann, S.A. & Chothia, C. J. Mol. Biol. 296, 1367–1383 (2000).

    Article  CAS  Google Scholar 

  8. Holmgren, A. & Branden, C.I. Nature 342, 248–251 (1989).

    Article  CAS  Google Scholar 

  9. Bjorkman, P.J. & Davis, M.M. Nature 334, 395–402 (1988).

    Article  Google Scholar 

  10. Boot, R.G., Renkema, G.H., Strijland, A., van Zonneveld, A.J. & Aerts, J.M. J. Biol. Chem. 270, 26252–26256 (1995).

    Article  CAS  Google Scholar 

  11. Chothia, C., Novotny, J., Bruccoleri, R. & Karplus, M. J. Mol. Biol. 186, 651–663 (1985).

    Article  CAS  Google Scholar 

  12. Pendleton, J.W., Nagai, B.K., Murtha, M.T. & Ruddle, F.H. Proc. Natl. Acad. Sci. USA 90, 6300–6304 (1993).

    Article  CAS  Google Scholar 

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Kaufman, J. The origins of the adaptive immune system: whatever next?. Nat Immunol 3, 1124–1125 (2002). https://doi.org/10.1038/ni1202-1124

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  • DOI: https://doi.org/10.1038/ni1202-1124

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