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Notchless T cell maturation?

Nature Immunology volume 2, pages 189–190 (2001)Cite this article

Notch is heavily involved in T cell lineage commitment . . . or is it? New data indicates that neither CD4 nor CD8 cell maturation is Notch1-dependent, whereas Notch1 is critical for earlier steps in T cell development.

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Figure 1: Notch effects defined by overexpression and by genetic disruption.

References

  1. Robey, E. et al. Cell 87, 483–492 (1996).

    Article  CAS  Google Scholar 

  2. Osborne, B. & Miele, L. Immunity 11, 653–663 (1999).

    Article  CAS  Google Scholar 

  3. Robey, E. Annu. Rev. Immunol. 17, 283–295 (1999).

    Article  CAS  Google Scholar 

  4. Deftos, M. L., & Bevan, M. J. Curr. Opin. Immunol. 12, 166–172 (2000).

    Article  CAS  Google Scholar 

  5. Wolfer, A. et al. Nature Immunol. 2, 235–241 (2001).

    Article  CAS  Google Scholar 

  6. Radtke, F. et al. Immunity 10, 547–558 (1999).

    Article  CAS  Google Scholar 

  7. Wilson, A., Ferrero, I., MacDonald, H. R. & Radtke, F. J. Immunol. 165, 5397–5400 (2000).

    Article  CAS  Google Scholar 

  8. Tomita, K. et al. Genes Dev. 13, 1203–1210 (1999).

    Article  CAS  Google Scholar 

  9. Kaneta, M. et al. J. Immunol. 164, 256–264 (2000).

    Article  CAS  Google Scholar 

  10. Pui, J. C. et al. Immunity 11, 299–308 (1999).

    Article  CAS  Google Scholar 

  11. Bigas, A., Martin, D. I. K. & Milner, L. A. Mol. Cell. Biol. 18, 2324–2333 (1998).

    Article  CAS  Google Scholar 

  12. Tan-Pertel, H. T. et al. J. Immunol. 165, 4428–4436 (2000).

    Article  CAS  Google Scholar 

  13. Bellavia et al. EMBO J. 19, 3337–3348 (2000).

    Article  CAS  Google Scholar 

  14. Deftos, M. L., Huang, E., Ojala, E. W., Forbush, K. A., & Bevan, M. J, Immunity 13, 73–84 (2000).

    Article  CAS  Google Scholar 

  15. Rothenberg, E. V. Curr. Opin. Genet. Dev. 10, 370–379 (2000)

    Article  CAS  Google Scholar 

  16. Washburn et al. Cell 88, 833–843 (1997).

    Article  CAS  Google Scholar 

  17. Jiang, R. et al. Genes Dev. 12, 1046–1057 (1998).

    Article  CAS  Google Scholar 

  18. Schroeder, T. & Just, U. EMBO J. 19, 2558–2568 (2000).

    Article  CAS  Google Scholar 

  19. Aster, J. C. et al. Mol. Cell. Biol. 20, 7505–7515 (2000).

    Article  CAS  Google Scholar 

Download references

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  1. Division of Biology 156-29, California Institute of Technology, Pasadena, 91125, CA, USA

    Ellen V. Rothenberg

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  1. Ellen V. Rothenberg
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Rothenberg, E. Notchless T cell maturation?. Nat Immunol 2, 189–190 (2001). https://doi.org/10.1038/85231

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