The E3 ubiquitin ligase Itch limits interleukin 17A (IL-17A)-mediated intestinal inflammation by targeting the transcription factor ROR-γt for proteasomal degradation.
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SUMOylation of ROR-γt inhibits IL-17 expression and inflammation via HDAC2
Nature Communications Open Access 30 October 2018
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S.R. is an employee of Genentech, and W.O. is an employee of Amgen.
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Rutz, S., Ouyang, W. The Itch to degrade ROR-γt. Nat Immunol 17, 898–900 (2016). https://doi.org/10.1038/ni.3516
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DOI: https://doi.org/10.1038/ni.3516
