Vesicular stomatitis virus, a single-stranded RNA virus, triggers activation of the serine-threonine kinases RIP1 and RIP3, which damages mitochondria by activating the GTPase DRP1. This results in excessive production of reactive oxygen species and subsequent activation of the NLRP3 inflammasome.
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Change history
10 April 2015
In the version of this article initially published, vesicular stomatitis virus was incorrectly identified as a double-stranded RNA virus. It should be identified as a single-stranded RNA virus throughout (and 'dsRNA' should be 'RNA' throughout the second paragraph and in the first sentence of the sixth paragraph and the seventh sentence of the seventh paragraph, and 'dsDNA' should be 'DNA' throughout). Also, the end of the second sentence of the second paragraph stated "TLR3 and TLR9 detect dsDNA viruses and dsRNA viruses, respectively". It should read as follows: "...TLR9 detects DNA viruses, and TLR3 and TLR7 detect RNA viruses." The correction notice posted on December 3 read "TLR3 and TLR9 detect RNA viruses" instead of "TLR3 and TLR7 detect RNA viruses." These errors have been corrected in the HTML and PDF versions of the article on 3 December 2014 and the correction notice on 10 April 2015.
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Rayamajhi, M., Miao, E. The RIP1-RIP3 complex initiates mitochondrial fission to fuel NLRP3. Nat Immunol 15, 1100–1102 (2014). https://doi.org/10.1038/ni.3030
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DOI: https://doi.org/10.1038/ni.3030
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