Signaling via the complement factors C3a and C5a regulates effector T cell responses. Evidence now links the absence of local complement activation with a default pathway that leads to the polarization of Foxp3+ regulatory T cells.
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Le Friec, G., Köhl, J. & Kemper, C. A complement a day keeps the Fox(p3) away. Nat Immunol 14, 110–112 (2013). https://doi.org/10.1038/ni.2515
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DOI: https://doi.org/10.1038/ni.2515
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