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Motifs for a deadly encounter

Nature Immunology volume 13, pages 205–206 (2012)Cite this article

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It is unknown how T cell antigen receptors from autoreactive CD8+ T cells recognize self. A new paper shows that an unorthodox, low-affinity way of interacting with targets may be at the basis of autoimmunity.

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Figure 1: How autoreactive CD8+ T cells may induce autoimmune disease.

Katie Vicari

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Authors and Affiliations

  1. Department of Rheumatology, Ken T. Coppieters is with the Unit for Molecular Immunology and Inflammation, Ghent University Hospital, Ghent, Belgium.,

    Ken T Coppieters

  2. Matthias G. von Herrath is with the Type 1 Diabetes Center, The La Jolla Institute for Allergy and Immunology, La Jolla, California, USA.,

    Matthias G von Herrath

Authors
  1. Ken T Coppieters
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  2. Matthias G von Herrath
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Correspondence to Matthias G von Herrath.

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The authors declare no competing financial interests.

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Coppieters, K., von Herrath, M. Motifs for a deadly encounter. Nat Immunol 13, 205–206 (2012). https://doi.org/10.1038/ni.2226

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