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A phagocyte dilemma...

Nature Immunology volume 12, pages 201–202 (2011)Cite this article

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The NADPH oxidase of professional phagocytes has an important role in host defense against certain microbes, including tuberculous mycobacteria. The identification of patients with rare inherited hypomorphic mutations in genes encoding components of this enzyme complex could produce new mechanistic insights.

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Figure 1: Professional phagocytic cells, including macrophages and dendritic cells, depend on a functional NADPH oxidase for normal clearance of microbes.

Katie Vicari

Change history

  • 10 March 2011

    In the version of this article initially published, the initials are incorrect for the first author of reference 3. The correct name is Bustamante, J. The error has been corrected in the HTML and PDF versions of the article.

References

  1. Baldridge, L.W. & Gerard, R.W. Am. J. Physiol. 103, 235–236 (1932).

    Article  Google Scholar 

  2. Segal, A.W. Annu. Rev. Immunol. 23, 197–223 (2005).

    Article  CAS  Google Scholar 

  3. Bustamante, J. et al. Nat. Immunol. 12, 213–221 (2011).

    Article  CAS  Google Scholar 

  4. Lee, P.P. et al. Pediatr. Infect. Dis. J. 27, 224–230 (2008).

    Article  Google Scholar 

  5. Kuhns, D.B. et al. N. Engl. J. Med. 363, 2600–2610 (2010).

    Article  CAS  Google Scholar 

  6. Segal, A.W., Garcia, R., Goldstone, H., Cross, A.R. & Jones, O.T. Biochem. J. 196, 363–367 (1981).

    Article  CAS  Google Scholar 

  7. Levy, R. & Malech, H.L. J. Immunol. 147, 3066–3071 (1991).

    CAS  PubMed  Google Scholar 

  8. Chetty, M., Thrasher, A.J., Abo, A. & Casimir, C.M. Biochem. J. 306, 141–145 (1995).

    Article  CAS  Google Scholar 

  9. Yu, L. et al. J. Biol. Chem. 274, 4364–4369 (1999).

    Article  CAS  Google Scholar 

  10. Huang, J. et al. Proc. Natl. Acad. Sci. USA 106, 6226–6231 (2009).

    Article  CAS  Google Scholar 

  11. Flannagan, R.S., Cosio, G. & Grinstein, S. Nat. Rev. Microbiol. 7, 355–366 (2009).

    Article  CAS  Google Scholar 

  12. Rybicka, J.M., Balce, D.R., Khan, M.F., Krohn, R.M. & Yates, R.M. Proc. Natl. Acad. Sci. USA 107, 10496–10501 (2010).

    Article  CAS  Google Scholar 

  13. Mantegazza, A.R. et al. Blood 112, 4712–4722 (2008).

    Article  CAS  Google Scholar 

  14. Rahman, F.Z., Hayee, B., Chee, R., Segal, A.W. & Smith, A.M. Immunology 128, 253–259 (2009).

    Article  CAS  Google Scholar 

  15. Shaw, G.B. The Doctor's Dilemma: A Tragedy 28 (Brentano's, New York, 1911).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Adrian J. Thrasher is with the Centre for Immunodeficiency, University College London Institute of Child Health, London, UK.,

    Adrian J Thrasher

  2. Anthony W. Segal is in the Department of Molecular Medicine, University College London, London, UK.,

    Anthony W Segal

Authors
  1. Adrian J Thrasher
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  2. Anthony W Segal
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Corresponding author

Correspondence to Adrian J Thrasher.

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The authors declare no competing financial interests.

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Thrasher, A., Segal, A. A phagocyte dilemma.... Nat Immunol 12, 201–202 (2011). https://doi.org/10.1038/ni0311-201

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