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Homeostasis of naive T cells: the Foxo that fixes

Nature Immunology volume 10, pages 133–134 (2009)Cite this article

The transcription factor Foxo1 regulates the homeostasis of naive peripheral T cells by 'translating' nutrient-availability signals into the expression of lymphoid tissue–homing molecules and the receptor for interleukin 7.

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Figure 1: Functions and interactions of Foxo1 and KLf2 in the homeostasis of naive T cells.

References

  1. Forster, R., Davalos-Misslitz, A.C. & Rot, A. Nat. Rev. Immunol. 8, 362–371 (2008).

    Article  Google Scholar 

  2. Tanchot, C., Lemonnier, F.A., Perarnau, B., Freitas, A.A. & Rocha, B. Science 276, 2057–2062 (1997).

    Article  CAS  Google Scholar 

  3. Di Santo, J.P. et al. J. Exp. Med. 189, 563–574 (1999).

    Article  CAS  Google Scholar 

  4. Kerdiles, Y.M. et al. Nat. Immunol. 10, 176–184 (2009).

    Article  CAS  Google Scholar 

  5. Lam, E.W., Francis, R.E. & Petkovic, M. Biochem. Soc. Trans. 34, 722–726 (2006).

    Article  CAS  Google Scholar 

  6. Calnan, D.R. & Brunet, A. Oncogene 27, 2276–2288 (2008).

    Article  CAS  Google Scholar 

  7. Tothova, Z. & Gilliland, D.G. Cell Stem Cell 1, 140–152 (2007).

    Article  CAS  Google Scholar 

  8. Almeida, A.R., Borghans, J.A. & Freitas, A.A. J. Exp. Med. 194, 591–599 (2001).

    Article  CAS  Google Scholar 

  9. Amin, R.H. & Schlissel, M.S. Nat. Immunol. 9, 613–622 (2008).

    Article  CAS  Google Scholar 

  10. Carlson, C.M. et al. Nature 442, 299–302 (2006).

    Article  CAS  Google Scholar 

  11. Sebzda, E., Zou, Z., Lee, J.S., Wang, T. & Kahn, M.L. Nat. Immunol. 9, 292–300 (2008).

    Article  CAS  Google Scholar 

  12. Bai, A., Hu, H., Yeung, M. & Chen, J. J. Immunol. 178, 7632–7639 (2007).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Antonio A. Freitas is with the Lymphocyte Population Biology Unit, Centre National de la Recherche Scientifique, Unités de Recherche Associées 1961, Institut Pasteur, Paris, 75015, France

    Antonio A Freitas

  2. Benedita Rocha is with the Institut National de la Santé et de la Recherche Médicale, U591, Institut Federatif de Recherche 94, Université Paris-Descartes, Paris, 75015, France

    Benedita Rocha

Authors
  1. Antonio A Freitas
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  2. Benedita Rocha
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Freitas, A., Rocha, B. Homeostasis of naive T cells: the Foxo that fixes. Nat Immunol 10, 133–134 (2009). https://doi.org/10.1038/ni0209-133

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