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Nature Immunology 10, 133 - 134 (2009)
doi:10.1038/ni0209-133
Homeostasis of naive T cells: the Foxo that fixes
Antonio A Freitas1 & Benedita Rocha2
- Antonio A. Freitas is with the Lymphocyte Population Biology Unit, Centre National de la Recherche Scientifique, Unités de Recherche Associées 1961, Institut Pasteur, Paris 75015, France.
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Benedita Rocha is with the Institut National de la Santé et de la Recherche Médicale, U591, Institut Federatif de Recherche 94, Université Paris-Descartes, Paris 75015, France.
e-mail: benedita.rocha@inserm.fr
Abstract
The transcription factor Foxo1 regulates the homeostasis of naive peripheral T cells by 'translating' nutrient-availability signals into the expression of lymphoid tissue–homing molecules and the receptor for interleukin 7.
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