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Nature Immunology 10, 19 (1 January 2009) | doi:10.1038/ni0109-19
Research Highlights
Abstract
Sequestering CD3|[epsi]| ITAMs Many cell surface receptors signal through cytoplasmic immunoreceptor tyrosine-based activation motifs (ITAMs). In Cell, Wucherpfennig and colleagues evaluate the functional relevance of membrane binding by ITAMs, a phenomenon described before, by using the CD3|[epsi]| cytoplasmic domain (CD3|[epsi]|CD) of the T cell antigen receptor (TCR) as an example.
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