Review abstract
Nature Immunology 10, 21 - 27 (2009)
Published online: 17 December 2008 | Corrected online: 16 January 2009 | doi:10.1038/ni.f.220
There is an Erratum (February 2009) associated with this Review.
Calcium signaling in immune cells
Monika Vig1 & Jean-Pierre Kinet1
Abstract
Calcium acts as a second messenger in many cell types, including lymphocytes. Resting lymphocytes maintain a low concentration of Ca2+. However, engagement of antigen receptors induces calcium influx from the extracellular space by several routes. A chief mechanism of Ca2+ entry in lymphocytes is through store-operated calcium (SOC) channels. The identification of two important molecular components of SOC channels, CRACM1 (the pore-forming subunit) and STIM1 (the sensor of stored calcium), has allowed genetic and molecular manipulation of the SOC entry pathway. In this review, we highlight advances in the understanding of Ca2+ signaling in lymphocytes with special emphasis on SOC entry. We also discuss outstanding questions and probable future directions of the field.
- Laboratory of Allergy and Immunology, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02115, USA.
Correspondence to: Monika Vig1 e-mail: mvig@bidmc.harvard.edu
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