Article abstract
Nature Immunology 10, 75 - 82 (2008)
Published online: 23 November 2008 | doi:10.1038/ni.1681
Influence of the transcription factor ROR
t on the development of NKp46+ cell populations in gut and skin
Carmelo Luci1,5, Ana Reynders1,5, Ivaylo I Ivanov2,5, Celine Cognet1,3, Laurent Chiche1,3, Lionel Chasson1, Jean Hardwigsen3, Esperanza Anguiano4, Jacques Banchereau4, Damien Chaussabel4, Marc Dalod1, Dan R Littman2, Eric Vivier1,3 & Elena Tomasello1
Abstract
NKp46+CD3- natural killer lymphocytes isolated from blood, lymphoid organs, lung, liver and uterus can produce granule-dependent cytotoxicity and interferon-
. Here we identify in dermis, gut lamina propria and cryptopatches distinct populations of NKp46+CD3- cells with a diminished capacity to degranulate and produce interferon-. In the gut, expression of the transcription factor RORt, which is involved in the development of lymphoid tissue–inducer cells, defined a previously unknown subset of NKp46+CD3- lymphocytes. Unlike RORt- lamina propria and dermis natural killer cells, gut RORt+NKp46+ cells produced interleukin 22. Our data show that lymphoid tissue–inducer cells and natural killer cells shared unanticipated similarities and emphasize the heterogeneity of NKp46+CD3- cells in innate immunity, lymphoid organization and local tissue repair.
- Centre d'Immunologie de Marseille-Luminy, Université de la Méditerranée, Institut National de la Santé et de la Recherche Médicale, U631, and Centre National de la Recherche Scientifique, Unité Mixte de Recherche 6102, case 906, Campus de Luminy, 13288 Marseille, France.
- The Kimmel Center for Biology and Medicine at the Skirball Institute and Howard Hughes Medical Institute, New York University School of Medicine, New York, New York 10016, USA.
- Hôpital de la Conception, Assistance Publique–Hôpitaux de Marseille, 13005 Marseille, France.
- Institut National de la Santé et de la Recherche Médicale, U899, Baylor Institute for Immunology Research, Dallas, Texas 75204, USA.
- These authors contributed equally to this work.
Correspondence to: Eric Vivier1,3Elena Tomasello1 e-mail: tomasello@ciml.univ-mrs.fr
Correspondence to: e-mail: vivier@ciml.univ-mrs.fr
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