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What is missing in immunology to understand immunity?

The question of how we acquire immunity has been investigated for a century or more. What have we learned from all of this endeavor? We asked Rolf Zinkernagel to provide, for the young investigator, food for thought about that which we still don't know—even if we think we do.

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Figure 1
Figure 2: Correlation of T cell responses with antigen localization, dose and timescale of antigen availability.

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Zinkernagel, R. What is missing in immunology to understand immunity?. Nat Immunol 1, 181–185 (2000). https://doi.org/10.1038/79712

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