Review Articles in 2020

Weyand and Goronzy discuss how the progressive loss of immune cell tolerance underlies the immunopathology associated with rheumatoid arthritis.

Terrando and colleagues review key mechanisms related to postoperative inflammation and the implications for developing perioperative neurocognitive disorders, with a focus on neuroinflammation and key cellular targets affected by surgical trauma.

Exposure to environmental pollutants can lead to immune system dysfunction with severe pathological consequences. Yamamoto and colleagues review the impact of pollutants on immune function and describe potential means to ameliorate these effects.

Pancreatic cancer has one of the worst survival outcomes of all cancers. Leinwand and Miller review the immunological landscape of pancreatic cancer, immune evasion mechanisms and the impact of the microbiota.

Koliaraki, Prados, Armaka & Kollias review the roles of fibroblastic mesenchymal cells in tissue homeostasis and immunopathologic diseases, including chronic inflammatory disease, tissue fibrosis and cancer.

In this Review, Smyth and colleagues provide an overview of recent advances in NK cell biology and discuss the progress and problems of NK cell–based cancer immunotherapies.

Tsokos reviews how the genetic, epigenetic and microbial environments influence innate and adaptive immune cells to drive immunopathology and organ damage in systemic lupus erythematosus.

The RNA modification N⁶-methyladenosine (m⁶A) plays an essential role in the regulation of immunity. Here, Shulman and Stern-Ginossar review the roles of m⁶A in controlling immune recognition, activation of innate and adaptive immune responses, and cell fate decisions.

Turley and Krishnamurty review new insights into lymph node stromal cells, a heterogeneous cell population that serves distinct functions during development, in maintaining lymphocyte homeostasis, and in coordinating immune responses.