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Radiation therapy has for decades been a standard form of treatment for many cancers. A Review by Galluzzi and colleagues explores the effects of radiation therapy in the context of the immune response.
The cytokine IL-7 plays essential roles in lymphocyte development. In their Review, Barata, Durum and Seddon describe IL-7’s key homeostatic functions and how its dysregulation can lead to autoinflammatory disease and cancer.
Ziegler and Corren review the cytokine TSLP, which regulates immune cell homeostasis at mucosal barriers, its role in allergic responses and newly discovered roles in cancer.
Ivashkiv and colleagues review the mechanisms by which IFN signatures and IFN epigenomic signatures are generated, as well as the functional consequences of these signatures in homeostasis and autoimmune diseases.
Xiaoxia Li and colleagues discuss the roles of signaling via IL-17 and its receptor and the implications of this axis for human health, noting their normal protective roles directed against fungi and bacteria as well as against pathological conditions in inflammation and cancer.
Checkpoint blockade has revolutionized cancer immunotherapy; however, this approach is effective in only a subset of cancers. In their Review, Vignali and colleagues discuss novel checkpoint targets and their biology and clinical potential.
High-grade glioblastoma demonstrates exceedingly poor patient survival rates. In their Review, Lim and colleagues describe the immunological mechanisms involved in the control of glioblastoma and the outlook for immunotherapy.
Pierce and colleagues discuss the cellular consequences of BCR signaling and recent advances in the understanding of B cell signaling in context in vivo.
Underlying inflammatory bowel disease is a complex web of activated immune cells. In this Review, Neurath delineates the cells, pathways and signals that contribute to the pathology of inflammatory bowel disease and the potential for therapeutic intervention.
In this Review, Pearce and colleagues discuss the metabolic adaptation of immune cells to various tissues and how functional adaptation compared with maladaptation within the niche can affect tissue homeostasis.
In this Review, Chavakis and colleagues discuss the mechanisms that govern the adaptation of hematopoietic progenitor cells to inflammation and its effects on the pathogenesis of human disease.
In this Review, Natoli and Ostuni discuss the mechanisms of adaptation and memory in immunity, with the aim of providing basic concepts that rationalize the properties and molecular bases of these essential processes.
Comprehensive immunity requires that cells sense intracellular pathogens. In their Review, Shao and colleagues describe mechanisms for the recognition of intracellular lipopolysaccharide and its essential role in responses to Gram-negative bacteria.
The skin and intestine are unique environments at the front line of the immune system. Powrie and colleagues review the distinctive adaptations acquired by regulatory T cells at these barrier surfaces.
