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TCR ligation activates multiple downstream pathways that lead to myriad functional outputs. Malissen and colleagues discuss how unbiased mass spectrometry using signaling hub 'bait' molecules, such as Lat, provides new insight into TCR signaling cascades.
Recent findings in the SIV-monkey model provide new evidence that stimulating effective CD8+ T cell immunity could provide protection. McMichael and Koff explore the path forward for optimizing such responses in humans.
