In 1934, Alfred Redfield discovered that the ratio of carbon to nitrogen to phosphorus is a nearly constant 106:16:1 throughout the world's oceans, in both phytoplankton biomass and in dissolved nutrient pools. This insight has proved invaluable in understanding marine biogeochemical cycles, but, 80 years later, subtle variations to this ratio have emerged. In this Web Focus, we present a collection of research and opinion pieces that examine nutrient dynamics across ancient and modern changing environments.