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Earlier this year, the 4th International Meeting on Unstable Microsatellites and Human Disease highlighted how far and fast the research of diseases associated with expanded repeats has advanced, and spotlighted the remaining recalcitrant problems.
The discovery that a differentiated somatic cell can give rise to a new organism through nuclear transfer cloning touched off a revolution in genetics. A new study outlining how to target genes serially in cows ushers in a new era in large-animal genetics.
The acquisition of an abnormal number of chromosomes is a hallmark of many human cancers. A new study indicates that unequal segregation of genetic material to daughter cells during cell division can also lead to premature senescence and accelerated onset of a variety of aging phenotypes.
Schizophrenia is a severely disabling disorder with a lifetime risk of ∼1%, which accounts for 2.8% of the global burden of disease. A new study provides evidence that a third gene in the 22q11 region is associated with schizophrenia, further confounding an already complicated story.
Factors that modify chromatin are crucial for regulating gene expression, but what, in turn, regulates these factors? A new study highlights the importance of signaling cascades in recruiting chromatin-remodeling enzymes to specific promoters during muscle differentiation.
The nucleotide excision repair system is essential for repairing DNA damage caused by exposure to sunlight. Now, parallel studies in yeast and individuals with a rare disease called trichothiodystrophy have identified a new component of the DNA repair and basal transcription factor TFIIH.
