Advance online publication


The latest research papers, published online ahead of print. These online versions are definitive and may be cited using the digital object identifier (DOI).

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Brief Communications

Common genetic variation near MC4R is associated with waist circumference and insulin resistance

John C Chambers, Paul Elliott, Delilah Zabaneh, Weihua Zhang, Yun Li, Philippe Froguel, David Balding, James Scott & Jaspal S Kooner

Published online: 04 May 2008; | doi:10.1038/ng.156


Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease

Sheila A Fisher, Mark Tremelling, Carl A Anderson, Rhian Gwilliam, Suzannah Bumpstead, Natalie J Prescott, Elaine R Nimmo, Dunecan Massey, Carlo Berzuini, Christopher Johnson, Jeffrey C Barrett, Fraser R Cummings, Hazel Drummond, Charlie W Lees, Clive M Onnie, Catherine E Hanson, Katarzyna Blaszczyk, Mike Inouye, Philip Ewels, Radhi Ravindrarajah, Andrew Keniry, Sarah Hunt, Martyn Carter, Nick Watkins, Willem Ouwehand, Cathryn M Lewis, Lon Cardon, the Wellcome Trust Case Control Consortium, Alan Lobo, Alastair Forbes, Jeremy Sanderson, Derek P Jewell, John C Mansfield, Panos Deloukas, Christopher G Mathew, Miles Parkes & Jack Satsangi

Published online: 27 April 2008; | doi:10.1038/ng.145


Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis

Andre Franke, Tobias Balschun, Tom H Karlsen, Jürgen Hedderich, Sandra May, Tim Lu, Dörthe Schuldt, Susanna Nikolaus, Philip Rosenstiel, Michael Krawczak & Stefan Schreiber

Published online: 27 April 2008; | doi:10.1038/ng.148


Common variants on chromosome 5p12 confer susceptibility to estrogen receptor–positive breast cancer

Simon N Stacey, Andrei Manolescu, Patrick Sulem, Steinunn Thorlacius, Sigurjon A Gudjonsson, Gudbjörn F Jonsson, Margret Jakobsdottir, Jon T Bergthorsson, Julius Gudmundsson, Katja K Aben, Luc J Strobbe, Dorine W Swinkels, K C Anton van Engelenburg, Brian E Henderson, Laurence N Kolonel, Loic Le Marchand, Esther Millastre, Raquel Andres, Berta Saez, Julio Lambea, Javier Godino, Eduardo Polo, Alejandro Tres, Simone Picelli, Johanna Rantala, Sara Margolin, Thorvaldur Jonsson, Helgi Sigurdsson, Thora Jonsdottir, Jon Hrafnkelsson, Jakob Johannsson, Thorarinn Sveinsson, Gardar Myrdal, Hlynur Niels Grimsson, Steinunn G Sveinsdottir, Kristin Alexiusdottir, Jona Saemundsdottir, Asgeir Sigurdsson, Jelena Kostic, Larus Gudmundsson, Kristleifur Kristjansson, Gisli Masson, James D Fackenthal, Clement Adebamowo, Temidayo Ogundiran, Olufunmilayo I Olopade, Christopher A Haiman, Annika Lindblom, Jose I Mayordomo, Lambertus A Kiemeney, Jeffrey R Gulcher, Thorunn Rafnar, Unnur Thorsteinsdottir, Oskar T Johannsson, Augustine Kong & Kari Stefansson

Published online: 27 April 2008; | doi:10.1038/ng.131


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Articles

Altered brain microRNA biogenesis contributes to phenotypic deficits in a 22q11-deletion mouse model

Kimberly L Stark, Bin Xu, Anindya Bagchi, Wen-Sung Lai, Hui Liu, Ruby Hsu, Xiang Wan, Paul Pavlidis, Alea A Mills, Maria Karayiorgou & Joseph A Gogos

Published online: 11 May 2008; | doi:10.1038/ng.138


Natural variation in Ghd7 is an important regulator of heading date and yield potential in rice

Weiya Xue, Yongzhong Xing, Xiaoyu Weng, Yu Zhao, Weijiang Tang, Lei Wang, Hongju Zhou, Sibin Yu, Caiguo Xu, Xianghua Li & Qifa Zhang

Published online: 04 May 2008; | doi:10.1038/ng.143


Identification of somatically acquired rearrangements in cancer using genome-wide massively parallel paired-end sequencing

Peter J Campbell, Philip J Stephens, Erin D Pleasance, Sarah O'Meara, Heng Li, Thomas Santarius, Lucy A Stebbings, Catherine Leroy, Sarah Edkins, Claire Hardy, Jon W Teague, Andrew Menzies, Ian Goodhead, Daniel J Turner, Christopher M Clee, Michael A Quail, Antony Cox, Clive Brown, Richard Durbin, Matthew E Hurles, Paul A W Edwards, Graham R Bignell, Michael R Stratton & P Andrew Futreal

Published online: 27 April 2008; | doi:10.1038/ng.128


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Letters


X-linked protocadherin 19 mutations cause female-limited epilepsy and cognitive impairment

Leanne M Dibbens, Patrick S Tarpey, Kim Hynes, Marta A Bayly, Ingrid E Scheffer, Raffaella Smith, Jamee Bomar, Edwina Sutton, Lucianne Vandeleur, Cheryl Shoubridge, Sarah Edkins, Samantha J Turner, Claire Stevens, Sarah O'Meara, Calli Tofts, Syd Barthorpe, Gemma Buck, Jennifer Cole, Kelly Halliday, David Jones, Rebecca Lee, Mark Madison, Tatiana Mironenko, Jennifer Varian, Sofie West, Sara Widaa, Paul Wray, John Teague, Ed Dicks, Adam Butler, Andrew Menzies, Andrew Jenkinson, Rebecca Shepherd, James F Gusella, Zaid Afawi, Aziz Mazarib, Miriam Y Neufeld, Sara Kivity, Dorit Lev, Tally Lerman-Sagie, Amos D Korczyn, Christopher P Derry, Grant R Sutherland, Kathryn Friend, Marie Shaw, Mark Corbett, Hyung-Goo Kim, Daniel H Geschwind, Paul Thomas, Eric Haan, Stephen Ryan, Shane McKee, Samuel F Berkovic, P Andrew Futreal, Michael R Stratton, John C Mulley & Jozef Gécz

Published online: 11 May 2008; | doi:10.1038/ng.149


De novo mutations in the gene encoding STXBP1 (MUNC18-1) cause early infantile epileptic encephalopathy

Hirotomo Saitsu, Mitsuhiro Kato, Takeshi Mizuguchi, Keisuke Hamada, Hitoshi Osaka, Jun Tohyama, Katsuhisa Uruno, Satoko Kumada, Kiyomi Nishiyama, Akira Nishimura, Ippei Okada, Yukiko Yoshimura, Syu-ichi Hirai, Tatsuro Kumada, Kiyoshi Hayasaka, Atsuo Fukuda, Kazuhiro Ogata & Naomichi Matsumoto

Published online: 11 May 2008; | doi:10.1038/ng.150


Common variants near MC4R are associated with fat mass, weight and risk of obesity

Ruth J F Loos, Cecilia M Lindgren, Shengxu Li, Eleanor Wheeler, Jing Hua Zhao, Inga Prokopenko, Michael Inouye, Rachel M Freathy, Antony P Attwood, Jacques S Beckmann, Sonja I Berndt, The Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial, Sven Bergmann, Amanda J Bennett, Sheila A Bingham, Murielle Bochud, Morris Brown, Stéphane Cauchi, John M Connell, Cyrus Cooper, George Davey Smith, Ian Day, Christian Dina, Subhajyoti De, Emmanouil T Dermitzakis, Alex S F Doney, Katherine S Elliott, Paul Elliott, David M Evans, I Sadaf Farooqi, Philippe Froguel, Jilur Ghori, Christopher J Groves, Rhian Gwilliam, David Hadley, Alistair S Hall, Andrew T Hattersley, Johannes Hebebrand, Iris M Heid, KORA, Blanca Herrera, Anke Hinney, Sarah E Hunt, Marjo-Riitta Jarvelin, Toby Johnson, Jennifer D M Jolley, Fredrik Karpe, Andrew Keniry, Kay-Tee Khaw, Robert N Luben, Massimo Mangino, Jonathan Marchini, Wendy L McArdle, Ralph McGinnis, David Meyre, Patricia B Munroe, Andrew D Morris, Andrew R Ness, Matthew J Neville, Alexandra C Nica, Ken K Ong, Stephen O'Rahilly, Katharine R Owen, Colin N A Palmer, Konstantinos Papadakis, Simon Potter, Anneli Pouta, Lu Qi, Nurses' Health Study, Joshua C Randall, Nigel W Rayner, Susan M Ring, Manjinder S Sandhu, André Scherag, Matthew A Sims, Kijoung Song, Nicole Soranzo, Elizabeth K Speliotes, Diabetes Genetics Initiative, Holly E Syddall, Sarah A Teichmann, Nicholas J Timpson, Jonathan H Tobias, Manuela Uda, The SardiNIA Study, Carla I Ganz Vogel, Chris Wallace, Dawn M Waterworth, Michael N Weedon, The Wellcome Trust Case Control Consortium, Cristen J Willer, FUSION, Vicki L Wraight, Xin Yuan, Eleftheria Zeggini, Joel N Hirschhorn, David P Strachan, Willem H Ouwehand, Mark J Caulfield, Nilesh J Samani, Timothy M Frayling, Peter Vollenweider, Gerard Waeber, Vincent Mooser, Panos Deloukas, Mark I McCarthy, Nicholas J Wareham & Inês Barroso

Published online: 04 May 2008; | doi:10.1038/ng.140


The mouse X chromosome is enriched for multicopy testis genes showing postmeiotic expression

Jacob L Mueller, Shantha K Mahadevaiah, Peter J Park, Peter E Warburton, David C Page & James M A Turner

Published online: 04 May 2008; | doi:10.1038/ng.126


Until print versions of AOP papers are published, they should be cited in the style "Author(s) Nature Genetics advance online publication, day month year (doi:10.1038/ngXXXXX)". Once the print version (identical to the AOP) is published, it should be cited as follows: "Author(s) Nature Genetics volume, page (year); advance online publication, (doi:10.1038/ngXXXXX)".

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