Advance online publication
The latest research papers, published online ahead of print. These online versions are definitive and may be cited using the digital object identifier (DOI).
About advance online publicationBrief Communications
Common genetic variation near MC4R is associated with waist circumference and insulin resistance
John C Chambers, Paul Elliott, Delilah Zabaneh, Weihua Zhang, Yun Li, Philippe Froguel, David Balding, James Scott & Jaspal S Kooner
Published online: 04 May 2008; | doi:10.1038/ng.156
Abstract - Common genetic variation near : MC4R: is associated with waist circumference and insulin resistance | Full Text - Common genetic variation near MC4R is associated with waist circumference and insulin resistance | PDF (117 KB) - Common genetic variation near MC4R is associated with waist circumference and insulin resistance | Supplementary information
Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease
Sheila A Fisher, Mark Tremelling, Carl A Anderson, Rhian Gwilliam, Suzannah Bumpstead, Natalie J Prescott, Elaine R Nimmo, Dunecan Massey, Carlo Berzuini, Christopher Johnson, Jeffrey C Barrett, Fraser R Cummings, Hazel Drummond, Charlie W Lees, Clive M Onnie, Catherine E Hanson, Katarzyna Blaszczyk, Mike Inouye, Philip Ewels, Radhi Ravindrarajah, Andrew Keniry, Sarah Hunt, Martyn Carter, Nick Watkins, Willem Ouwehand, Cathryn M Lewis, Lon Cardon, the Wellcome Trust Case Control Consortium, Alan Lobo, Alastair Forbes, Jeremy Sanderson, Derek P Jewell, John C Mansfield, Panos Deloukas, Christopher G Mathew, Miles Parkes & Jack Satsangi
Published online: 27 April 2008; | doi:10.1038/ng.145
Abstract - Genetic determinants of ulcerative colitis include the : ECM1: locus and five loci implicated in Crohn's disease | Full Text - Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease | PDF (141 KB) - Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease | Supplementary information
Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis
Andre Franke, Tobias Balschun, Tom H Karlsen, Jürgen Hedderich, Sandra May, Tim Lu, Dörthe Schuldt, Susanna Nikolaus, Philip Rosenstiel, Michael Krawczak & Stefan Schreiber
Published online: 27 April 2008; | doi:10.1038/ng.148
Abstract - Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis | Full Text - Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis | PDF (208 KB) - Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis | Supplementary information
Common variants on chromosome 5p12 confer susceptibility to estrogen receptor–positive breast cancer
Simon N Stacey, Andrei Manolescu, Patrick Sulem, Steinunn Thorlacius, Sigurjon A Gudjonsson, Gudbjörn F Jonsson, Margret Jakobsdottir, Jon T Bergthorsson, Julius Gudmundsson, Katja K Aben, Luc J Strobbe, Dorine W Swinkels, K C Anton van Engelenburg, Brian E Henderson, Laurence N Kolonel, Loic Le Marchand, Esther Millastre, Raquel Andres, Berta Saez, Julio Lambea, Javier Godino, Eduardo Polo, Alejandro Tres, Simone Picelli, Johanna Rantala, Sara Margolin, Thorvaldur Jonsson, Helgi Sigurdsson, Thora Jonsdottir, Jon Hrafnkelsson, Jakob Johannsson, Thorarinn Sveinsson, Gardar Myrdal, Hlynur Niels Grimsson, Steinunn G Sveinsdottir, Kristin Alexiusdottir, Jona Saemundsdottir, Asgeir Sigurdsson, Jelena Kostic, Larus Gudmundsson, Kristleifur Kristjansson, Gisli Masson, James D Fackenthal, Clement Adebamowo, Temidayo Ogundiran, Olufunmilayo I Olopade, Christopher A Haiman, Annika Lindblom, Jose I Mayordomo, Lambertus A Kiemeney, Jeffrey R Gulcher, Thorunn Rafnar, Unnur Thorsteinsdottir, Oskar T Johannsson, Augustine Kong & Kari Stefansson
Published online: 27 April 2008; | doi:10.1038/ng.131
Abstract - Common variants on chromosome 5p12 confer susceptibility to estrogen receptor-positive breast cancer | Full Text - Common variants on chromosome 5p12 confer susceptibility to estrogen receptor–positive breast cancer | PDF (184 KB) - Common variants on chromosome 5p12 confer susceptibility to estrogen receptor–positive breast cancer | Supplementary information
Articles
Altered brain microRNA biogenesis contributes to phenotypic deficits in a 22q11-deletion mouse model
Kimberly L Stark, Bin Xu, Anindya Bagchi, Wen-Sung Lai, Hui Liu, Ruby Hsu, Xiang Wan, Paul Pavlidis, Alea A Mills, Maria Karayiorgou & Joseph A Gogos
Published online: 11 May 2008; | doi:10.1038/ng.138
Abstract - Altered brain microRNA biogenesis contributes to phenotypic deficits in a 22q11-deletion mouse model | Full Text - Altered brain microRNA biogenesis contributes to phenotypic deficits in a 22q11-deletion mouse model | PDF (464 KB) - Altered brain microRNA biogenesis contributes to phenotypic deficits in a 22q11-deletion mouse model | Supplementary information
Natural variation in Ghd7 is an important regulator of heading date and yield potential in rice
Weiya Xue, Yongzhong Xing, Xiaoyu Weng, Yu Zhao, Weijiang Tang, Lei Wang, Hongju Zhou, Sibin Yu, Caiguo Xu, Xianghua Li & Qifa Zhang
Published online: 04 May 2008; | doi:10.1038/ng.143
Abstract - Natural variation in : Ghd7: is an important regulator of heading date and yield potential in rice | Full Text - Natural variation in Ghd7 is an important regulator of heading date and yield potential in rice | PDF (463 KB) - Natural variation in Ghd7 is an important regulator of heading date and yield potential in rice | Supplementary information
Identification of somatically acquired rearrangements in cancer using genome-wide massively parallel paired-end sequencing
Peter J Campbell, Philip J Stephens, Erin D Pleasance, Sarah O'Meara, Heng Li, Thomas Santarius, Lucy A Stebbings, Catherine Leroy, Sarah Edkins, Claire Hardy, Jon W Teague, Andrew Menzies, Ian Goodhead, Daniel J Turner, Christopher M Clee, Michael A Quail, Antony Cox, Clive Brown, Richard Durbin, Matthew E Hurles, Paul A W Edwards, Graham R Bignell, Michael R Stratton & P Andrew Futreal
Published online: 27 April 2008; | doi:10.1038/ng.128
Abstract - Identification of somatically acquired rearrangements in cancer using genome-wide massively parallel paired-end sequencing | Full Text - Identification of somatically acquired rearrangements in cancer using genome-wide massively parallel paired-end sequencing | PDF (1,082 KB) - Identification of somatically acquired rearrangements in cancer using genome-wide massively parallel paired-end sequencing | Supplementary information
Letters
Regulatory change in YABBY-like transcription factor led to evolution of extreme fruit size during tomato domestication
Bin Cong, Luz S Barrero & Steven D Tanksley
Published online: 11 May 2008; | doi:10.1038/ng.144
First Paragraph - Regulatory change in YABBY-like transcription factor led to evolution of extreme fruit size during tomato domestication | Full Text - Regulatory change in YABBY-like transcription factor led to evolution of extreme fruit size during tomato domestication | PDF (278 KB) - Regulatory change in YABBY-like transcription factor led to evolution of extreme fruit size during tomato domestication | Supplementary information
X-linked protocadherin 19 mutations cause female-limited epilepsy and cognitive impairment
Leanne M Dibbens, Patrick S Tarpey, Kim Hynes, Marta A Bayly, Ingrid E Scheffer, Raffaella Smith, Jamee Bomar, Edwina Sutton, Lucianne Vandeleur, Cheryl Shoubridge, Sarah Edkins, Samantha J Turner, Claire Stevens, Sarah O'Meara, Calli Tofts, Syd Barthorpe, Gemma Buck, Jennifer Cole, Kelly Halliday, David Jones, Rebecca Lee, Mark Madison, Tatiana Mironenko, Jennifer Varian, Sofie West, Sara Widaa, Paul Wray, John Teague, Ed Dicks, Adam Butler, Andrew Menzies, Andrew Jenkinson, Rebecca Shepherd, James F Gusella, Zaid Afawi, Aziz Mazarib, Miriam Y Neufeld, Sara Kivity, Dorit Lev, Tally Lerman-Sagie, Amos D Korczyn, Christopher P Derry, Grant R Sutherland, Kathryn Friend, Marie Shaw, Mark Corbett, Hyung-Goo Kim, Daniel H Geschwind, Paul Thomas, Eric Haan, Stephen Ryan, Shane McKee, Samuel F Berkovic, P Andrew Futreal, Michael R Stratton, John C Mulley & Jozef Gécz
Published online: 11 May 2008; | doi:10.1038/ng.149
First Paragraph - X-linked protocadherin 19 mutations cause female-limited epilepsy and cognitive impairment | Full Text - X-linked protocadherin 19 mutations cause female-limited epilepsy and cognitive impairment | PDF (885 KB) - X-linked protocadherin 19 mutations cause female-limited epilepsy and cognitive impairment | Supplementary information
De novo mutations in the gene encoding STXBP1 (MUNC18-1) cause early infantile epileptic encephalopathy
Hirotomo Saitsu, Mitsuhiro Kato, Takeshi Mizuguchi, Keisuke Hamada, Hitoshi Osaka, Jun Tohyama, Katsuhisa Uruno, Satoko Kumada, Kiyomi Nishiyama, Akira Nishimura, Ippei Okada, Yukiko Yoshimura, Syu-ichi Hirai, Tatsuro Kumada, Kiyoshi Hayasaka, Atsuo Fukuda, Kazuhiro Ogata & Naomichi Matsumoto
Published online: 11 May 2008; | doi:10.1038/ng.150
First Paragraph - De novo: mutations in the gene encoding STXBP1 (MUNC18-1) cause early infantile epileptic encephalopathy | Full Text - De novo mutations in the gene encoding STXBP1 (MUNC18-1) cause early infantile epileptic encephalopathy | PDF (1,006 KB) - De novo mutations in the gene encoding STXBP1 (MUNC18-1) cause early infantile epileptic encephalopathy | Supplementary information
Common variants near MC4R are associated with fat mass, weight and risk of obesity
Ruth J F Loos, Cecilia M Lindgren, Shengxu Li, Eleanor Wheeler, Jing Hua Zhao, Inga Prokopenko, Michael Inouye, Rachel M Freathy, Antony P Attwood, Jacques S Beckmann, Sonja I Berndt, The Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial, Sven Bergmann, Amanda J Bennett, Sheila A Bingham, Murielle Bochud, Morris Brown, Stéphane Cauchi, John M Connell, Cyrus Cooper, George Davey Smith, Ian Day, Christian Dina, Subhajyoti De, Emmanouil T Dermitzakis, Alex S F Doney, Katherine S Elliott, Paul Elliott, David M Evans, I Sadaf Farooqi, Philippe Froguel, Jilur Ghori, Christopher J Groves, Rhian Gwilliam, David Hadley, Alistair S Hall, Andrew T Hattersley, Johannes Hebebrand, Iris M Heid, KORA, Blanca Herrera, Anke Hinney, Sarah E Hunt, Marjo-Riitta Jarvelin, Toby Johnson, Jennifer D M Jolley, Fredrik Karpe, Andrew Keniry, Kay-Tee Khaw, Robert N Luben, Massimo Mangino, Jonathan Marchini, Wendy L McArdle, Ralph McGinnis, David Meyre, Patricia B Munroe, Andrew D Morris, Andrew R Ness, Matthew J Neville, Alexandra C Nica, Ken K Ong, Stephen O'Rahilly, Katharine R Owen, Colin N A Palmer, Konstantinos Papadakis, Simon Potter, Anneli Pouta, Lu Qi, Nurses' Health Study, Joshua C Randall, Nigel W Rayner, Susan M Ring, Manjinder S Sandhu, André Scherag, Matthew A Sims, Kijoung Song, Nicole Soranzo, Elizabeth K Speliotes, Diabetes Genetics Initiative, Holly E Syddall, Sarah A Teichmann, Nicholas J Timpson, Jonathan H Tobias, Manuela Uda, The SardiNIA Study, Carla I Ganz Vogel, Chris Wallace, Dawn M Waterworth, Michael N Weedon, The Wellcome Trust Case Control Consortium, Cristen J Willer, FUSION, Vicki L Wraight, Xin Yuan, Eleftheria Zeggini, Joel N Hirschhorn, David P Strachan, Willem H Ouwehand, Mark J Caulfield, Nilesh J Samani, Timothy M Frayling, Peter Vollenweider, Gerard Waeber, Vincent Mooser, Panos Deloukas, Mark I McCarthy, Nicholas J Wareham & Inês Barroso
Published online: 04 May 2008; | doi:10.1038/ng.140
First Paragraph - Common variants near : MC4R: are associated with fat mass, weight and risk of obesity | Full Text - Common variants near MC4R are associated with fat mass, weight and risk of obesity | PDF (391 KB) - Common variants near MC4R are associated with fat mass, weight and risk of obesity | Supplementary information
The mouse X chromosome is enriched for multicopy testis genes showing postmeiotic expression
Jacob L Mueller, Shantha K Mahadevaiah, Peter J Park, Peter E Warburton, David C Page & James M A Turner
Published online: 04 May 2008; | doi:10.1038/ng.126
First Paragraph - The mouse X chromosome is enriched for multicopy testis genes showing postmeiotic expression | Full Text - The mouse X chromosome is enriched for multicopy testis genes showing postmeiotic expression | PDF (559 KB) - The mouse X chromosome is enriched for multicopy testis genes showing postmeiotic expression | Supplementary information
Until print versions of AOP papers are published, they should be cited in the style "Author(s) Nature Genetics advance online publication, day month year (doi:10.1038/ngXXXXX)". Once the print version (identical to the AOP) is published, it should be cited as follows: "Author(s) Nature Genetics volume, page (year); advance online publication, (doi:10.1038/ngXXXXX)".
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