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Letter

Nature Genetics 41, 807–810 (1 July 2009) | doi:10.1038/ng.394

A genome-wide association study of testicular germ cell tumor

Elizabeth A Rapley , Clare Turnbull , Ali Amin Al Olama , Emmanouil T Dermitzakis , Rachel Linger , Robert A Huddart , Anthony Renwick , Deborah Hughes , Sarah Hines , Sheila Seal , Jonathan Morrison , Jeremie Nsengimana , Panagiotis Deloukas , Nazneen Rahman , D Timothy Bishop , Douglas F Easton & Michael R Stratton

We conducted a genome-wide association study for testicular germ cell tumor (TGCT), genotyping 307,666 SNPs in 730 cases and 1,435 controls from the UK and replicating associations in a further 571 cases and 1,806 controls. We found strong evidence for susceptibility loci on chromosome 5 (per allele OR = 1.37 (95% CI = 1.19–1.58), P = 3 |[times]| 10|[minus]|13), chromosome 6 (OR = 1.50 (95% CI = 1.28–1.75), P = 10|[minus]|13) and chromosome 12 (OR = 2.55 (95% CI = 2.05–3.19), P = 10|[minus]|31).