Brief Communication abstract
Nature Genetics 41, 1058 - 1060 (2009)
Published online: 20 September 2009 | doi:10.1038/ng.452
Multiple loci on 8q24 associated with prostate cancer susceptibility
Ali Amin Al Olama1, Zsofia Kote-Jarai2, Graham G Giles3,4, Michelle Guy2, Jonathan Morrison1, Gianluca Severi3,4, Daniel A Leongamornlert2, Malgorzata Tymrakiewicz2, Sameer Jhavar2, Ed Saunders2, John L Hopper4, Melissa C Southey5, Kenneth R Muir6, Dallas R English4, David P Dearnaley2,7, Audrey T Ardern-Jones7, Amanda L Hall2,7, Lynne T O'Brien2, Rosemary A Wilkinson2, Emma Sawyer2, Artitaya Lophatananon6, The UK Genetic Prostate Cancer Study Collaborators/British Association of Urological Surgeons' Section of Oncology12, The UK Prostate testing for cancer and Treatment study (ProtecT Study) Collaborators12, Alan Horwich2,7, Robert A Huddart2,7, Vincent S Khoo2,7, Christopher C Parker2,7, Christopher J Woodhouse7, Alan Thompson7, Tim Christmas7, Chris Ogden7, Colin Cooper2, Jenny L Donovan8, Freddie C Hamdy9, David E Neal10,11, Rosalind A Eeles2,7,13 & Douglas F Easton1,13
Previous studies have identified multiple loci on 8q24 associated with prostate cancer risk. We performed a comprehensive analysis of SNP associations across 8q24 by genotyping tag SNPs in 5,504 prostate cancer cases and 5,834 controls. We confirmed associations at three previously reported loci and identified additional loci in two other linkage disequilibrium blocks (rs1006908: per-allele OR = 0.87, P = 7.9 
10-8; rs620861: OR = 0.90, P = 4.8 10-8). Eight SNPs in five linkage disequilibrium blocks were independently associated with prostate cancer susceptibility.
- Cancer Research UK Genetic Epidemiology Unit, University of Cambridge, Cambridge, UK.
- The Institute of Cancer Research, Sutton, Surrey, UK.
- Cancer Epidemiology Centre, The Cancer Council Victoria, Carlton, Victoria, Australia.
- Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, The University of Melbourne, Carlton, Victoria, Australia.
- Genetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne, Parkville, Victoria, Australia.
- University of Nottingham Medical School, Queens Medical Centre, Nottingham, UK.
- The Royal Marsden National Health Service Foundation Trust, Sutton, Surrey, and London, UK.
- Department of Social Medicine, University of Bristol, Bristol, UK.
- Nuffield Department of Surgery, University of Oxford, Oxford, UK.
- Cancer Research UK Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK.
- Surgical Oncology (Uro-Oncology), Departments of Oncology and Surgery, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.
- Full lists of members are provided in the Supplementary Note.
- These authors contributed equally to this work.
Correspondence to: Douglas F Easton1,13 e-mail: douglas@srl.cam.ac.uk
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