Brief Communication abstract


Nature Genetics 40, 1282 - 1284 (2008)
Published online: 12 October 2008 | doi:10.1038/ng.255

Male-pattern baldness susceptibility locus at 20p11

J Brent Richards1,2, Xin Yuan3, Frank Geller4, Dawn Waterworth3, Veronique Bataille1, Daniel Glass1, Kijoung Song3, Gerard Waeber5, Peter Vollenweider5, Katja K H Aben6,7, Lambertus A Kiemeney8,9, Bragi Walters4, Nicole Soranzo1,10, Unnur Thorsteinsdottir4, Augustine Kong4, Thorunn Rafnar4, Panos Deloukas10, Patrick Sulem4, Hreinn Stefansson4, Kari Stefansson4, Tim D Spector1,11 & Vincent Mooser3,11

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We conducted a genome-wide association study for androgenic alopecia in 1,125 men and identified a newly associated locus at chromosome 20p11.22, confirmed in three independent cohorts (n = 1,650; OR = 1.60, P = 1.1 times 10-14 for rs1160312). The one man in seven who harbors risk alleles at both 20p11.22 and AR (encoding the androgen receptor) has a sevenfold-increased odds of androgenic alopecia (OR = 7.12, P = 3.7 times 10-15).

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  1. Department of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK.
  2. Department of Medicine, Jewish General Hospital, Faculty of Medicine, McGill University, Montréal, Québec H3T 1E2, Canada.
  3. Genetics Division, GlaxoSmithKline, King of Prussia, Pennsylvania 19406, USA.
  4. deCODE Genetics, Reykjavik 101, Iceland.
  5. Department of Internal Medicine, CHUV University Hospital, Lausanne 1011, Switzerland.
  6. Comprehensive Cancer Center IKO, Radboud University Nijmegen Medical Center, Nijmegen 6501 BG, The Netherlands.
  7. Department of Epidemiology and Biostatistics, Radboud University Nijmegen Medical Center, Nijmegen 6500 HB, The Netherlands.
  8. Department of Epidemiology and Biostatistics, Radboud University Nijmegen Medical Center, Nijmegen 6500 HB, The Netherlands.
  9. Department of Urology, Radboud University Nijmegen Medical Center, Nijmegen 6525 GA, The Netherlands.
  10. Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK.
  11. These authors contributed equally to this work.

Correspondence to: Tim D Spector1,11 e-mail: tim.spector@kcl.ac.uk