Brief Communication abstract
Nature Genetics 40, 1282 - 1284 (2008)
Published online: 12 October 2008 | doi:10.1038/ng.255
Male-pattern baldness susceptibility locus at 20p11
J Brent Richards1,2, Xin Yuan3, Frank Geller4, Dawn Waterworth3, Veronique Bataille1, Daniel Glass1, Kijoung Song3, Gerard Waeber5, Peter Vollenweider5, Katja K H Aben6,7, Lambertus A Kiemeney8,9, Bragi Walters4, Nicole Soranzo1,10, Unnur Thorsteinsdottir4, Augustine Kong4, Thorunn Rafnar4, Panos Deloukas10, Patrick Sulem4, Hreinn Stefansson4, Kari Stefansson4, Tim D Spector1,11 & Vincent Mooser3,11
We conducted a genome-wide association study for androgenic alopecia in 1,125 men and identified a newly associated locus at chromosome 20p11.22, confirmed in three independent cohorts (n = 1,650; OR = 1.60, P = 1.1 
10-14 for rs1160312). The one man in seven who harbors risk alleles at both 20p11.22 and AR (encoding the androgen receptor) has a sevenfold-increased odds of androgenic alopecia (OR = 7.12, P = 3.7 10-15).
- Department of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK.
- Department of Medicine, Jewish General Hospital, Faculty of Medicine, McGill University, Montréal, Québec H3T 1E2, Canada.
- Genetics Division, GlaxoSmithKline, King of Prussia, Pennsylvania 19406, USA.
- deCODE Genetics, Reykjavik 101, Iceland.
- Department of Internal Medicine, CHUV University Hospital, Lausanne 1011, Switzerland.
- Comprehensive Cancer Center IKO, Radboud University Nijmegen Medical Center, Nijmegen 6501 BG, The Netherlands.
- Department of Epidemiology and Biostatistics, Radboud University Nijmegen Medical Center, Nijmegen 6500 HB, The Netherlands.
- Department of Epidemiology and Biostatistics, Radboud University Nijmegen Medical Center, Nijmegen 6500 HB, The Netherlands.
- Department of Urology, Radboud University Nijmegen Medical Center, Nijmegen 6525 GA, The Netherlands.
- Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK.
- These authors contributed equally to this work.
Correspondence to: Tim D Spector1,11 e-mail: tim.spector@kcl.ac.uk
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