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Susceptibility variants for male-pattern baldness on chromosome 20p11

Nature Genetics volume 40, pages 1279–1281 (2008)Cite this article

Abstract

We carried out a genome-wide association study in 296 individuals with male-pattern baldness (androgenetic alopecia) and 347 controls. We then investigated the 30 best SNPs in an independent replication sample and found highly significant association for five SNPs on chromosome 20p11 (rs2180439 combined P = 2.7 × 10−15). No interaction was detected with the X-chromosomal androgen receptor locus, suggesting that the 20p11 locus has a role in a yet-to-be-identified androgen-independent pathway.

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Figure 1: Genome-wide scan for association with AGA and details of the region 21,571,171– 22,321,597 on chromosome 20p11.

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References

  1. Nyholt, D.R., Gillespie, N.A., Heath, A.C. & Martin, N.G. J. Invest. Dermatol. 121, 1561–1564 (2003).

    Article  Google Scholar 

  2. Ellis, J.A., Stebbing, M. & Harrap, S.B. J. Invest. Dermatol. 116, 452–455 (2001).

    Article  CAS  Google Scholar 

  3. Hillmer, A.M. et al. Am. J. Hum. Genet. 77, 140–148 (2005).

    Article  CAS  Google Scholar 

  4. Ellis, J.A. et al. Hum. Genet. 121, 451–457 (2007).

    Article  Google Scholar 

  5. Lotufo, P.A., Chae, C.U., Ajani, U.A., Hennekens, C.H. & Manson, J.E. Arch. Intern. Med. 160, 165–171 (2000).

    Article  CAS  Google Scholar 

  6. Matilainen, V., Koskela, P. & Keinänen-Kiukaanniemi, S. Lancet 356, 1165–1166 (2000).

    Article  CAS  Google Scholar 

  7. Hamilton, J.B. Ann. NY Acad. Sci. 53, 708–728 (1951).

    Article  CAS  Google Scholar 

  8. Norwood, O.T. South. Med. J. 68, 1359–1365 (1975).

    Article  CAS  Google Scholar 

  9. The Wellcome Trust Case Control Consortium. Nature 447, 661–678 (2007).

  10. Cordell, H.J. & Clayton, D.G. Am. J. Hum. Genet. 70, 124–141 (2002).

    Article  CAS  Google Scholar 

  11. Kleinjan, D.A. et al. Dev. Biol. 299, 563–581 (2006).

    Article  CAS  Google Scholar 

  12. Paik, J.H., Yoon, J.B., Sim, W.Y., Kim, B.S. & Kim, N.I. Br. J. Dermatol. 145, 95–99 (2001).

    Article  CAS  Google Scholar 

  13. Hillmer, A.M. et al. Am. J. Hum. Genet. 82, 737–743 (2008).

    Article  CAS  Google Scholar 

  14. Risch, N. & Merikangas, K. Science 273, 1516–1517 (1996).

    Article  CAS  Google Scholar 

  15. Barrett, J.C., Fry, B., Maller, J. & Daly, M.J. Bioinformatics 21, 263–265 (2005).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

We thank all probands for participating in the study and providing blood samples. This study was supported by the Deutsche Forschungsgemeinschaft (FOR 423 and Emmy Noether) and the Alfried Krupp von Bohlen und Halbach-Stiftung. The Heinz Nixdorf Recall cohort was established with the support of the Heinz Nixdorf Foundation (G. Schmidt, Chairman).

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Author notes

  1. Axel M Hillmer and Felix F Brockschmidt: These authors contributed equally to this work.

Authors and Affiliations

  1. Department of Genomics, Life & Brain Center, University of Bonn, D-53127, Bonn, Germany

    Axel M Hillmer, Felix F Brockschmidt, Stefan Herms, Thomas W Mühleisen, Margrieta A Alblas, Roman Reinartz, Sven Cichon & Markus M Nöthen

  2. Department of Dermatology, University of Düsseldorf, D-40225, Düsseldorf, Germany

    Sandra Hanneken, Sibylle Eigelshoven, Anne-Katrin Kortüm & Roland Kruse

  3. Institute for Medical Biometry, Informatics and Epidemiology, University of Bonn, D-53105, Bonn, Germany

    Michael Steffens, Antonia Flaquer, Tim Becker, Max P Baur & Thomas F Wienker

  4. Genetic Epidemiology, Queensland Institute of Medical Research, QLD 4006, Brisbane, Australia

    Dale R Nyholt, Zhen Zhen Zhao, Grant W Montgomery & Nicholas G Martin

  5. Institute for Medical Informatics, Biometry and Epidemiology, University Duisburg-Essen, D-45122, Essen, Germany

    Susanne Moebus & Karl-Heinz Jöckel

  6. Clinic of Endocrinology, Central Laboratory Unit Research and Education, University Hospital of Essen, University Duisburg-Essen, D-45122, Essen, Germany

    Martina Bröcker-Preuss

  7. Clinic of Cardiology, West-German Heart Center Essen, University Duisburg-Essen, D-45122, Essen, Germany

    Raimund Erbel

  8. Institute of Human Genetics, University of Bonn, D-53111, Bonn, Germany

    Regina C Betz, Sven Cichon, Peter Propping & Markus M Nöthen

Authors
  1. Axel M Hillmer
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  2. Felix F Brockschmidt
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  13. Nicholas G Martin
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  18. Martina Bröcker-Preuss
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  19. Raimund Erbel
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Contributions

M.M.N. and R.K. initiated the study; A.M.H. and F.F.B. contributed to the study design; M.M.N. and A.M.H. coordinated the work and prepared the manuscript, with feedback from the other authors; R.K., S. Hanneken, S.E., and A.-K.K. diagnosed the affected and unaffected German individuals and collected the blood samples; S.M., K.-H.J., M.B.-P. and R.E. recruited and characterized German population controls; N.G.M. and D.R.N. recruited and characterized Australian sample; F.F.B., T.W.M., M.A.A., Z.Z.Z., G.W.M. and R.R. prepared DNA and performed genotyping; M.S., A.F., S. Herms, T.B., and D.R.N. performed statistical analysis; F.F.B. performed expression analysis. M.M.N., A.M.H., F.F.B., T.B., N.G.M, D.R.N., T.F.W., M.P.B., S.C., P.P., and R.C.B. analyzed and interpreted data.

Corresponding author

Correspondence to Axel M Hillmer.

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Competing interests

M.M.N., R.K., A.M.H. and F.F.B. declare competing financial interests because of their patent application (European patent 08 00 6933.9).

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Supplementary Tables 1–4, Supplementary Figures 1–4 and Supplementary Methods (PDF 412 kb)

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Hillmer, A., Brockschmidt, F., Hanneken, S. et al. Susceptibility variants for male-pattern baldness on chromosome 20p11. Nat Genet 40, 1279–1281 (2008). https://doi.org/10.1038/ng.228

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