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Brief Communication

Nature Genetics 40, 1156–1159 (1 October 2008) | doi:10.1038/ng.218

Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13

Anne Barton , Wendy Thomson , Xiayi Ke , Steve Eyre , Anne Hinks , John Bowes , Darren Plant , Laura J Gibbons , Anthony G Wilson , Deborah E Bax , Ann W Morgan , Paul Emery , Sophia Steer , Lynne Hocking , David M Reid , Paul Wordsworth , Pille Harrison & Jane Worthington

The WTCCC study identified 49 SNPs putatively associated with rheumatoid arthritis at P = 1 |[times]| 10|[minus]|4 |[minus]| 1 |[times]| 10|[minus]|5 (tier 3). Here we show that three of these SNPs, mapping to chromosome 10p15 (rs4750316), 12q13 (rs1678542) and 22q13 (rs3218253), are also associated (trend P = 4 |[times]| 10|[minus]|5, P = 4 |[times]| 10|[minus]|4 and P = 4 |[times]| 10|[minus]|4, respectively) in a validation study of 4,106 individuals with rheumatoid arthritis and an expanded reference group of 11,238 subjects, confirming them as true susceptibility loci in individuals of European ancestry.