Brief Communication abstract
Nature Genetics 40, 23 - 25 (2008)
Published online: 2 December 2007 | doi:10.1038/ng.2007.48
Psoriasis is associated with increased 
-defensin genomic copy number
Edward J Hollox1, Ulrike Huffmeier2, Patrick L J M Zeeuwen3, Raquel Palla4, Jesús Lascorz2, Diana Rodijk-Olthuis3, Peter C M van de Kerkhof3, Heiko Traupe5, Gys de Jongh3, Martin den Heijer6, André Reis2, John A L Armour4,7 & Joost Schalkwijk3,7
Psoriasis is a common inflammatory skin disease with a strong genetic component. We analyzed the genomic copy number polymorphism of the 
-defensin region on human chromosome 8 in 179 Dutch individuals with psoriasis and 272 controls and in 319 German individuals with psoriasis and 305 controls. Comparisons in both cohorts showed a significant association between higher genomic copy number for -defensin genes and risk of psoriasis.
- Department of Genetics, University of Leicester, Leicester LE1 7RH, UK.
- Institute of Human Genetics, Friedrich Alexander University Erlangen Nuremberg, 91054 Erlangen, Germany.
- Department of Dermatology, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, 652 GA Nijmegen, The Netherlands.
- Institute of Genetics, University of Nottingham, Nottingham NG7 2UH, UK.
- Department of Dermatology, University of Münster, NG7 2UH Münster, Germany.
- Department of Endocrinology and Department of Epidemiology and Biostatistics, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands.
- These authors contributed equally to this work.
Correspondence to: John A L Armour4,7 e-mail: john.armour@nottingham.ac.uk
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