Brief Communication abstract


Nature Genetics 40, 23 - 25 (2008)
Published online: 2 December 2007 | doi:10.1038/ng.2007.48

Psoriasis is associated with increased bold beta-defensin genomic copy number

Edward J Hollox1, Ulrike Huffmeier2, Patrick L J M Zeeuwen3, Raquel Palla4, Jesús Lascorz2, Diana Rodijk-Olthuis3, Peter C M van de Kerkhof3, Heiko Traupe5, Gys de Jongh3, Martin den Heijer6, André Reis2, John A L Armour4,7 & Joost Schalkwijk3,7

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Psoriasis is a common inflammatory skin disease with a strong genetic component. We analyzed the genomic copy number polymorphism of the beta-defensin region on human chromosome 8 in 179 Dutch individuals with psoriasis and 272 controls and in 319 German individuals with psoriasis and 305 controls. Comparisons in both cohorts showed a significant association between higher genomic copy number for beta-defensin genes and risk of psoriasis.

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  1. Department of Genetics, University of Leicester, Leicester LE1 7RH, UK.
  2. Institute of Human Genetics, Friedrich Alexander University Erlangen Nuremberg, 91054 Erlangen, Germany.
  3. Department of Dermatology, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, 652 GA Nijmegen, The Netherlands.
  4. Institute of Genetics, University of Nottingham, Nottingham NG7 2UH, UK.
  5. Department of Dermatology, University of Münster, NG7 2UH Münster, Germany.
  6. Department of Endocrinology and Department of Epidemiology and Biostatistics, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands.
  7. These authors contributed equally to this work.

Correspondence to: John A L Armour4,7 e-mail: john.armour@nottingham.ac.uk



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