Letter abstract
Nature Genetics 39, 870 - 874 (2007)
Published online: 27 May 2007 | doi:10.1038/ng2075
A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer
David J Hunter1,2,3,4, Peter Kraft2, Kevin B Jacobs5, David G Cox1,2, Meredith Yeager4,6, Susan E Hankinson1, Sholom Wacholder4, Zhaoming Wang4,6, Robert Welch4,6, Amy Hutchinson4,6, Junwen Wang4,6, Kai Yu4, Nilanjan Chatterjee4, Nick Orr7, Walter C Willett1,8, Graham A Colditz9, Regina G Ziegler4, Christine D Berg10, Saundra S Buys11, Catherine A McCarty12, Heather Spencer Feigelson13, Eugenia E Calle13, Michael J Thun13, Richard B Hayes4, Margaret Tucker4, Daniela S Gerhard14, Joseph F Fraumeni, Jr4, Robert N Hoover4, Gilles Thomas4 & Stephen J Chanock4,7
We conducted a genome-wide association study (GWAS) of breast cancer by genotyping 528,173 SNPs in 1,145 postmenopausal women of European ancestry with invasive breast cancer and 1,142 controls. We identified four SNPs in intron 2 of FGFR2 (which encodes a receptor tyrosine kinase and is amplified or overexpressed in some breast cancers) that were highly associated with breast cancer and confirmed this association in 1,776 affected individuals and 2,072 controls from three additional studies. Across the four studies, the association with all four SNPs was highly statistically significant (Ptrend for the most strongly associated SNP (rs1219648) = 1.1 
10-10; population attributable risk = 16%). Four SNPs at other loci most strongly associated with breast cancer in the initial GWAS were not associated in the replication studies. Our summary results from the GWAS are available online in a form that should speed the identification of additional risk loci.
- Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.
- Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA.
- Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA.
- Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), US National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Bethesda, Maryland 20892, USA.
- Bioinformed Consulting Services, Gaithersburg, Maryland 20877, USA.
- SAIC-Frederick, NCI-FCRDC, Frederick, Maryland 21702, USA.
- Pediatric Oncology Branch, Center for Cancer Research, NCI, NIH, DHHS, Bethesda, Maryland 20892, USA.
- Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA.
- Washington University School of Medicine, St. Louis, Missouri 63130, USA.
- Division of Cancer Prevention, NCI, NIH, DHHS, Bethesda, Maryland 20892, USA.
- Department of Internal Medicine, University of Utah, Salt Lake City, Utah 84112, USA.
- The Center for Human Genetics, Marshfield Clinic Research Foundation, Marshfield, Wisconsin 54449, USA.
- Department of Epidemiology and Surveillance Research, American Cancer Society, Atlanta, Georgia 30329, USA.
- Office of Cancer Genomics, NCI, NIH, DHHS, Bethesda, Maryland 20892, USA.
Correspondence to: David J Hunter1,2,3,4 e-mail: dhunter@hsph.harvard.edu
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
RESEARCH
Multiple loci identified in a genome-wide association study of prostate cancerNature Genetics Letter (01 Mar 2008)
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controlsNature Article (07 Jun 2007)
A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer riskNature Genetics Brief Communication (01 Nov 2007)
44Ky44OO44Og6KaP5qih44Gu6Zai6YCj56CU56m244Gr44KI44Gj44GmU01BRDc=44Gu5LiA6Iis55qE44Gq5a++56uL6YG65Lyd5a2Q44GM57WQ6IW455u06IW455mM44Gu44Oq44K544Kv44Gr5b2x6Z+/44KS5LiO44GI44KL44GT44Go44GM44KP44GL44Gj44GfNature Genetics Brief Communication (01 Nov 2007)
See all 14 matches for Research