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Letter

Nature Genetics 39, 638–644 (1 May 2007) | doi:10.1038/ng2015

Multiple regions within 8q24 independently affect risk for prostate cancer

Christopher A Haiman , Nick Patterson , Matthew L Freedman , Simon R Myers , Malcolm C Pike , Alicja Waliszewska , Julie Neubauer , Arti Tandon , Christine Schirmer , Gavin J McDonald , Steven C Greenway , Daniel O Stram , Loic Le Marchand , Laurence N Kolonel , Melissa Frasco , David Wong , Loreall C Pooler , Kristin Ardlie , Ingrid Oakley-Girvan , Alice S Whittemore , Kathleen A Cooney , Esther M John , Sue A Ingles , David Altshuler , Brian E Henderson & David Reich

After the recent discovery that common genetic variation in 8q24 influences inherited risk of prostate cancer, we genotyped 2,973 SNPs in up to 7,518 men with and without prostate cancer from five populations. We identified seven risk variants, five of them previously undescribed, spanning 430 kb and each independently predicting risk for prostate cancer (P = 7.9 |[times]| 10|[minus]|19 for the strongest association, and P |[minus]|4 for five of the variants, after controlling for each of the others).