Access

Letter

Nature Genetics 39, 1500–1506 (1 December 2007) | doi:10.1038/ng.2007.15

Loss of Trim24 (Tif1|[alpha]|) gene function confers oncogenic activity to retinoic acid receptor alpha

Konstantin Khetchoumian , Marius Teletin , Johan Tisserand , Manuel Mark , Benjamin Herquel , Mihaela Ignat , Jessica Zucman-Rossi , Florence Cammas , Thierry Lerouge , Christelle Thibault , Daniel Metzger , Pierre Chambon & R|[eacute]|gine Losson

Hepatocellular carcinoma (HCC) is a major cause of death worldwide. Here, we provide evidence that the ligand-dependent nuclear receptor co-regulator Trim24 (also known as Tif1α) functions in mice as a liver-specific tumor suppressor.