Lessons in the genomic diversity of malaria - p1

doi:10.1038/ng0107-1

Abstract - Lessons in the genomic diversity of malaria | Full Text - Lessons in the genomic diversity of malaria | PDF (46 KB) - Lessons in the genomic diversity of malaria

Awesome, in brief - p3

doi:10.1038/ng0107-3

Full Text - Awesome, in brief | PDF (57 KB) - Awesome, in brief

Toward a malaria haplotype map - pp5 - 6

Jane M Carlton

doi:10.1038/ng0107-5

Full Text - Toward a malaria haplotype map | PDF (57 KB) - Toward a malaria haplotype map

See also: Letter by Volkman et al. | Letter by Jeffares et al. | Letter by Mu et al.

Following the herd - pp7 - 8

Stephen P Wooding

doi:10.1038/ng0107-7

Full Text - Following the herd | PDF (170 KB) - Following the herd

See also: Article by Tishkoff et al.

Sending out an SOS - pp8 - 9

Kevin Shannon & Gideon Bollag

doi:10.1038/ng0107-8

Full Text - Sending out an SOS | PDF (136 KB) - Sending out an SOS

See also: Letter by Roberts et al. | Letter by Tartaglia et al.

Chaotic license for genetic instability and cancer - pp10 - 11

Anindya Dutta

doi:10.1038/ng0107-10

Full Text - Chaotic license for genetic instability and cancer | PDF (254 KB) - Chaotic license for genetic instability and cancer

See also: Letter by Shima et al.

Telomeres, p21 and the cancer-aging hypothesis - pp11 - 12

Jessica F Bell & Norman E Sharpless

doi:10.1038/ng0107-11

Full Text - Telomeres, p21 and the cancer-aging hypothesis | PDF (205 KB) - Telomeres, p21 and the cancer-aging hypothesis

See also: Letter by Choudhury et al.

Touching base - p13

doi:10.1038/ng0107-13

Full Text - Touching base | PDF (102 KB) - Touching base

Research highlights - p15

doi:10.1038/ng0107-15

Full Text - Research highlights | PDF (39 KB) - Research highlights

Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database - pp17 - 23

Lars Bertram, Matthew B McQueen, Kristina Mullin, Deborah Blacker & Rudolph E Tanzi

doi:10.1038/ng1934

Abstract - Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database | Full Text - Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database | PDF (124 KB) - Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database | Supplementary information

Mutations in the gene encoding the synaptic scaffolding protein SHANK3 are associated with autism spectrum disorders - pp25 - 27

Christelle M Durand, Catalina Betancur, Tobias M Boeckers, Juergen Bockmann, Pauline Chaste, Fabien Fauchereau, Gudrun Nygren, Maria Rastam, I Carina Gillberg, Henrik Anckarsäter, Eili Sponheim, Hany Goubran-Botros, Richard Delorme, Nadia Chabane, Marie-Christine Mouren-Simeoni, Philippe de Mas, Eric Bieth, Bernadette Rogé, Delphine Héron, Lydie Burglen, Christopher Gillberg, Marion Leboyer & Thomas Bourgeron

doi:10.1038/ng1933

Abstract - Mutations in the gene encoding the synaptic scaffolding protein : : SHANK3: : are associated with autism spectrum disorders | Full Text - Mutations in the gene encoding the synaptic scaffolding protein SHANK3 are associated with autism spectrum disorders | PDF (251 KB) - Mutations in the gene encoding the synaptic scaffolding protein SHANK3 are associated with autism spectrum disorders | Supplementary information

The gene encoding adipose triglyceride lipase (PNPLA2) is mutated in neutral lipid storage disease with myopathy - pp28 - 30

Judith Fischer, Caroline Lefèvre, Eva Morava, Jean-Marie Mussini, Pascal Laforêt, Anne Negre-Salvayre, Mark Lathrop & Robert Salvayre

doi:10.1038/ng1951

Abstract - The gene encoding adipose triglyceride lipase (: : PNPLA2: : ) is mutated in neutral lipid storage disease with myopathy | Full Text - The gene encoding adipose triglyceride lipase (PNPLA2) is mutated in neutral lipid storage disease with myopathy | PDF (305 KB) - The gene encoding adipose triglyceride lipase (PNPLA2) is mutated in neutral lipid storage disease with myopathy | Supplementary information

Convergent adaptation of human lactase persistence in Africa and Europe - pp31 - 40

Sarah A Tishkoff, Floyd A Reed, Alessia Ranciaro, Benjamin F Voight, Courtney C Babbitt, Jesse S Silverman, Kweli Powell, Holly M Mortensen, Jibril B Hirbo, Maha Osman, Muntaser Ibrahim, Sabah A Omar, Godfrey Lema, Thomas B Nyambo, Jilur Ghori, Suzannah Bumpstead, Jonathan K Pritchard, Gregory A Wray & Panos Deloukas

doi:10.1038/ng1946

Abstract - Convergent adaptation of human lactase persistence in Africa and Europe | Full Text - Convergent adaptation of human lactase persistence in Africa and Europe | PDF (501 KB) - Convergent adaptation of human lactase persistence in Africa and Europe | Supplementary information

See also: News and Views by Wooding

Integrative molecular concept modeling of prostate cancer progression - pp41 - 51

Scott A Tomlins, Rohit Mehra, Daniel R Rhodes, Xuhong Cao, Lei Wang, Saravana M Dhanasekaran, Shanker Kalyana-Sundaram, John T Wei, Mark A Rubin, Kenneth J Pienta, Rajal B Shah & Arul M Chinnaiyan

doi:10.1038/ng1935

Abstract - Integrative molecular concept modeling of prostate cancer progression | Full Text - Integrative molecular concept modeling of prostate cancer progression | PDF (597 KB) - Integrative molecular concept modeling of prostate cancer progression | Supplementary information

PDGF signaling specificity is mediated through multiple immediate early genes - pp52 - 60

Jennifer Schmahl, Christopher S Raymond & Philippe Soriano

doi:10.1038/ng1922

Abstract - PDGF signaling specificity is mediated through multiple immediate early genes | Full Text - PDGF signaling specificity is mediated through multiple immediate early genes | PDF (694 KB) - PDGF signaling specificity is mediated through multiple immediate early genes | Supplementary information

Genome-wide analysis of Arabidopsis thaliana DNA methylation uncovers an interdependence between methylation and transcription - pp61 - 69

Daniel Zilberman, Mary Gehring, Robert K Tran, Tracy Ballinger & Steven Henikoff

doi:10.1038/ng1929

Abstract - Genome-wide analysis of : Arabidopsis thaliana: DNA methylation uncovers an interdependence between methylation and transcription | Full Text - Genome-wide analysis of Arabidopsis thaliana DNA methylation uncovers an interdependence between methylation and transcription | PDF (1,443 KB) - Genome-wide analysis of Arabidopsis thaliana DNA methylation uncovers an interdependence between methylation and transcription | Supplementary information

Germline gain-of-function mutations in SOS1 cause Noonan syndrome - pp70 - 74

Amy E Roberts, Toshiyuki Araki, Kenneth D Swanson, Kate T Montgomery, Taryn A Schiripo, Victoria A Joshi, Li Li, Yosuf Yassin, Alex M Tamburino, Benjamin G Neel & Raju S Kucherlapati

doi:10.1038/ng1926

First paragraph - Germline gain-of-function mutations in : : SOS1: : cause Noonan syndrome | Full Text - Germline gain-of-function mutations in SOS1 cause Noonan syndrome | PDF (407 KB) - Germline gain-of-function mutations in SOS1 cause Noonan syndrome | Supplementary information

See also: News and Views by Shannon & Bollag

Gain-of-function SOS1 mutations cause a distinctive form of Noonan syndrome - pp75 - 79

Marco Tartaglia, Len A Pennacchio, Chen Zhao, Kamlesh K Yadav, Valentina Fodale, Anna Sarkozy, Bhaswati Pandit, Kimihiko Oishi, Simone Martinelli, Wendy Schackwitz, Anna Ustaszewska, Joel Martin, James Bristow, Claudio Carta, Francesca Lepri, Cinzia Neri, Isabella Vasta, Kate Gibson, Cynthia J Curry, Juan Pedro López Siguero, Maria Cristina Digilio, Giuseppe Zampino, Bruno Dallapiccola, Dafna Bar-Sagi & Bruce D Gelb

doi:10.1038/ng1939

Abstract - Gain-of-function : : SOS1: : mutations cause a distinctive form of Noonan syndrome | Full Text - Gain-of-function SOS1 mutations cause a distinctive form of Noonan syndrome | PDF (291 KB) - Gain-of-function SOS1 mutations cause a distinctive form of Noonan syndrome | Supplementary information

See also: News and Views by Shannon & Bollag

Mutations in SYNE1 lead to a newly discovered form of autosomal recessive cerebellar ataxia - pp80 - 85

François Gros-Louis, Nicolas Dupré, Patrick Dion, Michael A Fox, Sandra Laurent, Steve Verreault, Joshua R Sanes, Jean-Pierre Bouchard & Guy A Rouleau

doi:10.1038/ng1927

First paragraph - Mutations in : : SYNE1: : lead to a newly discovered form of autosomal recessive cerebellar ataxia | Full Text - Mutations in SYNE1 lead to a newly discovered form of autosomal recessive cerebellar ataxia | PDF (503 KB) - Mutations in SYNE1 lead to a newly discovered form of autosomal recessive cerebellar ataxia | Supplementary information

HAX1 deficiency causes autosomal recessive severe congenital neutropenia (Kostmann disease) - pp86 - 92

Christoph Klein, Magda Grudzien, Giridharan Appaswamy, Manuela Germeshausen, Inga Sandrock, Alejandro A Schäffer, Chozhavendan Rathinam, Kaan Boztug, Beate Schwinzer, Nima Rezaei, Georg Bohn, Malin Melin, Göran Carlsson, Bengt Fadeel, Niklas Dahl, Jan Palmblad, Jan-Inge Henter, Cornelia Zeidler, Bodo Grimbacher & Karl Welte

doi:10.1038/ng1940

First paragraph - : HAX1: : deficiency causes autosomal recessive severe congenital neutropenia (Kostmann disease) | Full Text - HAX1 deficiency causes autosomal recessive severe congenital neutropenia (Kostmann disease) | PDF (544 KB) - HAX1 deficiency causes autosomal recessive severe congenital neutropenia (Kostmann disease) | Supplementary information

A viable allele of Mcm4 causes chromosome instability and mammary adenocarcinomas in mice - pp93 - 98

Naoko Shima, Ana Alcaraz, Ivan Liachko, Tavanna R Buske, Catherine A Andrews, Robert J Munroe, Suzanne A Hartford, Bik K Tye & John C Schimenti

doi:10.1038/ng1936

First paragraph - A viable allele of : : Mcm4: : causes chromosome instability and mammary adenocarcinomas in mice | Full Text - A viable allele of Mcm4 causes chromosome instability and mammary adenocarcinomas in mice | PDF (413 KB) - A viable allele of Mcm4 causes chromosome instability and mammary adenocarcinomas in mice | Supplementary information

See also: News and Views by Dutta

Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation - pp99 - 105

Aaheli Roy Choudhury, Zhenyu Ju, Meta W Djojosubroto, Andrea Schienke, Andre Lechel, Sonja Schaetzlein, Hong Jiang, Anna Stepczynska, Chunfang Wang, Jan Buer, Han-Woong Lee, Thomas von Zglinicki, Arnold Ganser, Peter Schirmacher, Hiromitsu Nakauchi & K Lenhard Rudolph

doi:10.1038/ng1937

First paragraph - : Cdkn1a: : deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation | Full Text - Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation | PDF (513 KB) - Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation | Supplementary information

See also: News and Views by Bell & Sharpless

Wnt--catenin signaling initiates taste papilla development - pp106 - 112

Fei Liu, Shoba Thirumangalathu, Natalie M Gallant, Steven H Yang, Cristi L Stoick-Cooper, Seshamma T Reddy, Thomas Andl, Makoto M Taketo, Andrzej A Dlugosz, Randall T Moon, Linda A Barlow & Sarah E Millar

doi:10.1038/ng1932

First paragraph - Wnt-[beta]-catenin signaling initiates taste papilla development | Full Text - Wnt--catenin signaling initiates taste papilla development | PDF (988 KB) - Wnt--catenin signaling initiates taste papilla development | Supplementary information

A genome-wide map of diversity in Plasmodium falciparum - pp113 - 119

Sarah K Volkman, Pardis C Sabeti, David DeCaprio, Daniel E Neafsey, Stephen F Schaffner, Danny A Milner, Jr, Johanna P Daily, Ousmane Sarr, Daouda Ndiaye, Omar Ndir, Soulyemane Mboup, Manoj T Duraisingh, Amanda Lukens, Alan Derr, Nicole Stange-Thomann, Skye Waggoner, Robert Onofrio, Liuda Ziaugra, Evan Mauceli, Sante Gnerre, David B Jaffe, Joanne Zainoun, Roger C Wiegand, Bruce W Birren, Daniel L Hartl, James E Galagan, Eric S Lander & Dyann F Wirth

doi:10.1038/ng1930

First paragraph - A genome-wide map of diversity in : Plasmodium falciparum | Full Text - A genome-wide map of diversity in Plasmodium falciparum | PDF (363 KB) - A genome-wide map of diversity in Plasmodium falciparum | Supplementary information

See also: News and Views by Carlton

Genome variation and evolution of the malaria parasite Plasmodium falciparum - pp120 - 125

Daniel C Jeffares, Arnab Pain, Andrew Berry, Anthony V Cox, James Stalker, Catherine E Ingle, Alan Thomas, Michael A Quail, Kyle Siebenthall, Anne-Catrin Uhlemann, Sue Kyes, Sanjeev Krishna, Chris Newbold, Emmanouil T Dermitzakis & Matthew Berriman

doi:10.1038/ng1931

First paragraph - Genome variation and evolution of the malaria parasite : Plasmodium falciparum | Full Text - Genome variation and evolution of the malaria parasite Plasmodium falciparum | PDF (452 KB) - Genome variation and evolution of the malaria parasite Plasmodium falciparum | Supplementary information

See also: News and Views by Carlton

Genome-wide variation and identification of vaccine targets in the Plasmodium falciparum genome - pp126 - 130

Jianbing Mu, Philip Awadalla, Junhui Duan, Kate M McGee, Jon Keebler, Karl Seydel, Gilean A T McVean & Xin-zhuan Su

doi:10.1038/ng1924

First paragraph - Genome-wide variation and identification of vaccine targets in the : Plasmodium falciparum: genome | Full Text - Genome-wide variation and identification of vaccine targets in the Plasmodium falciparum genome | PDF (220 KB) - Genome-wide variation and identification of vaccine targets in the Plasmodium falciparum genome | Supplementary information

See also: News and Views by Carlton

Corrigendum: Cxorf6 is a causative gene for hypospadias - p131

Maki Fukami, Yuka Wada, Kanako Miyabayashi, Ichizo Nishino, Tomonobu Hasegawa, Giovanna Camerino, Christine Kretz, Anna Buj-Bello, Jocelyn Laporte, Gen Yamada, Ken-ichirou Morohashi & Tsutomu Ogata

doi:10.1038/ng0107-131

Full Text - Corrigendum: Cxorf6 is a causative gene for hypospadias | PDF (30 KB) - Corrigendum: Cxorf6 is a causative gene for hypospadias