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Volume 38 Issue 12, December 2006

Cover art: Plume Poppy by Bryan Nash Gill bgill0536@charter.net Photography by Allen Phillips allen.phillips@wadsworthatheneum.org

Volume 38 Issue 12

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Editorial

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Book Review

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News & Views

  • Sequencing of genomes, including that of humans, has revolutionized our understanding of genome organization and accelerated the hunt for disease-causing mutations. New studies by the Human Epigenome Project (HEP) now highlight the importance and complexity of cytosine DNA methylation in tissue-specific regulation of gene expression.

    • Romulo M Brena
    • Tim H-M Huang
    • Christoph Plass
    News & Views

  • A new study reports mutations in PLCE1 responsible for an autosomal recessive nephrotic syndrome in children that presents with diffuse mesangial sclerosis or focal segmental glomerulosclerosis. Remarkably, two affected individuals treated at an early phase of life responded to either steroids or cyclosporin A, opening a window of opportunity for therapy.

    • Susan E Quaggin
    News & Views

  • Analysis of the phenotype of mouse germ cells deficient for the retinoic acid–responsive gene Stra8 provides insight into the timing of the commitment to enter meiosis in mammals. The observations suggest that, as in other eukaryotes, this commitment precedes (or coincides with) the commitment to premeiotic DNA replication.

    • Debra J Wolgemuth
    News & Views

  • Many clinical syndromes result from deletion or duplication of regions within the human genome. Two new studies demonstrate strong connections between such events and allelic recombination in humans, which in the future may enable researchers to better predict the locations of unstable genomic regions.

    • Simon R Myers
    • Steven A McCarroll
    News & Views
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Brief Communication

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Article

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Letter

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Technical Report

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