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Volume 36 Issue 4, April 2004

'He looks at her DNA' by Hunter O'Reilly Drawn with Photobacterium phosphoreumhttp://www.hunteroreilly.com

Volume 36 Issue 4

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Editorial

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Obituary

  • Marjorie had that all-too-rare ability to see biological phenomena through the eyes of equations and mathematical proofs, but many in her remarkably wide circle of friends will remember Marjorie more for her effervescent attitude and high-spirited approach to life than for her sterling science.

    • John C Avise
    Obituary
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Book Review

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News & Views

  • The Wip1 phosphatase is encoded by an oncogene that is amplified in several forms of human cancer, including breast cancer. Ablation of this gene confers resistance to breast tumors induced by certain oncogenes.

    • René Bernards
    News & Views

  • New evidence suggests that Wnt signaling can be suppressed or further activated by upstream signals, even though the pathway seems to be constitutively activated by downstream mutations in cancer cells.

    • M Mark Taketo
    News & Views

  • The ubiquitous USF proteins regulate the transcription of many genes involved in lipid and glucose homeostasis. A new study provides genetic evidence that USF1 may confer susceptibility to high blood lipid levels.

    • Carol C Shoulders
    News & Views

  • The association of diseases with genes is complex, even among mendelian disorders. A new study shows that mutations in the gene encoding filamin B (FLNB) cause four distinct disorders of human skeletal development.

    • Leslie G Biesecker
    News & Views

  • Understanding how gene expression is regulated on a global scale is important for determining how basic processes such as cell proliferation, cell differentiation and responses to environmental signals are controlled. Three papers now show that it is possible to identify binding sites for key transcription factors in human cells on a chromosome level.

    • Ghia Euskirchen
    • Michael Snyder
    News & Views
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Perspective

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Brief Communication

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Article

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Letter

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Erratum

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Corrigendum

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