Access

Letter

Nature Genetics 35, 76–83 (1 September 2003) | doi:10.1038/ng1219

Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes

Chiara Zuccato , Marzia Tartari , Andrea Crotti , Donato Goffredo , Marta Valenza , Luciano Conti , Tiziana Cataudella , Blair R Leavitt , Michael R Hayden , T|[otilde]|nis Timmusk , Dorotea Rigamonti & Elena Cattaneo

Huntingtin protein is mutated in Huntington disease. We previously reported that wild-type but not mutant huntingtin stimulates transcription of the gene encoding brain-derived neurotrophic factor (BDNF; ref.