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An expanded role for wild-type huntingtin in neuronal transcription

Nature Genetics volume 35, pages 13–14 (2003)Cite this article

Huntington disease is caused by a polyglutamine repeat expansion in the huntingtin protein. A new study highlights an important role for the normal protein in neuronal transcriptional regulation.

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Figure 1: Wild-type huntingtin (Htt) sequesters REST in the cytosol.

Renee Lucas

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  1. The author is in the Department of Psychiatry and Human Behavior, Department of Biological Chemistry, University of California Irvine, Irvine, 92697-4260, California, USA

    Leslie Michels Thompson

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  1. Leslie Michels Thompson
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Thompson, L. An expanded role for wild-type huntingtin in neuronal transcription. Nat Genet 35, 13–14 (2003). https://doi.org/10.1038/ng0903-13

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