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Letter

Nature Genetics 32, 655–660 (1 December 2002) | doi:10.1038/ng1022

A mouse model of human L1 retrotransposition

Eric M. Ostertag , Ralph J. DeBerardinis , John L. Goodier , Yue Zhang , Nuo Yang , George L. Gerton & Haig H. Kazazian

The L1 retrotransposon has had an immense impact on the size and structure of the human genome through a variety of mechanisms, including insertional mutagenesis. To study retrotransposition in a living organism, we created a mouse model of human L1 retrotransposition.