L1 retrotransposition is ongoing, and has dramatically affected the evolution and structure of mammalian genomes. Despite their impact on the genome, little is known about when, where or how frequently L1s retrotranspose in vivo. The establishment of a mouse model of human L1 retrotransposition is a major step toward answering these questions.
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References
Lander, E.S. et al. Nature 409, 860–921 (2001).
Sassaman, D.M. et al. Nature Genet. 16, 37–43 (1997).
Moran, J.V. & Gilbert, N. in Mobile DNA II (eds Craig, N., Craggie, R., Gellert, M. & Lambowitz, A.) 836–869 (ASM Press, Washington, DC, 2002).
Boeke, J.D. Nature Genet. 16, 6–7 (1997).
Esnault, C., Maestre, J. & Heidmann, T. Nature Genet. 24, 363–367 (2000).
Wei, W. et al. Mol. Cell. Biol. 21, 1429–1439 (2001).
Branciforte, D. & Martin, S.L. Mol. Cell. Biol. 14, 2584–2592 (1994).
Trelogan, S.A. & Martin, S.L. Proc. Natl Acad. Sci. USA 92, 1520–1524 (1995).
Ostertag, E.M. et al. Nature Genet. 32 (2002); advance online publication, 4 November 2002 (doi:10.1038/ng1022).
Nakanishi, T. et al. FEBS Lett. 449, 277–283 (1999).
Moran, J.V. et al. Cell 87, 917–927 (1996).
Gilbert, N., Lutz-Prigge, S. & Moran, J.V. Cell 110, 315–325 (2002).
Symer, D.E. et al. Cell 110, 327–338 (2002).
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Athanikar, J., Morrish, T. & Moran, J. Of man in mice. Nat Genet 32, 562–563 (2002). https://doi.org/10.1038/ng1043
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DOI: https://doi.org/10.1038/ng1043
