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Letter

Nature Genetics 32, 438–442 (1 November 2002) | doi:10.1038/ng1005

Genome-wide DNA replication profile for Drosophila melanogaster: a link between transcription and replication timing

Dirk Sch|[uuml]|beler , David Scalzo , Charles Kooperberg , Bas van Steensel , Jeffrey Delrow & Mark Groudine

Replication of the genome before mitotic cell division is a highly regulated process that ensures the fidelity of DNA duplication. DNA replication initiates at specific locations, termed origins of replication, and progresses in a defined temporal order during the S phase of the cell cycle.