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Replication timing and metazoan evolution

Nature Genetics volume 32, pages 336–337 (2002)Cite this article

The long-presumed relationship between transcriptional activity of genes and their replication early in S-phase was challenged when a whole-genome analysis of replication timing in budding yeast found no such relationship. A new study reports the first genome-wide comparison of replication timing and gene expression in a multicellular organism, revealing a strong correlation between the two. This difference may reflect levels of nuclear organization that are important in the context of tissue-specific gene regulation.

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  1. Department of Biochemistry and Molecular Biology, S.U.N.Y. Upstate Medical University, Syracuse, 13210, New York, USA

    David M. Gilbert

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  1. David M. Gilbert
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Gilbert, D. Replication timing and metazoan evolution. Nat Genet 32, 336–337 (2002). https://doi.org/10.1038/ng1102-336

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