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Letter

Nature Genetics 29, 223–228 (1 October 2001) | doi:10.1038/ng1001-223

Genetic variation in the 5q31 cytokine gene cluster confers susceptibility to Crohn disease

John D. Rioux , Mark J. Daly , Mark S. Silverberg , Kerstin Lindblad , Hillary Steinhart , Zane Cohen , Terrye Delmonte , Kerry Kocher , Katie Miller , Sheila Guschwan , Edward J. Kulbokas , Sinead O'Leary , Ellen Winchester , Ken Dewar , Todd Green , Valerie Stone , Christine Chow , Albert Cohen , Diane Langelier , Gilles Lapointe , Daniel Gaudet , Janet Faith , Nancy Branco , Shelley B. Bull , Robin S. McLeod , Anne M. Griffiths , Alain Bitton , Gordon R. Greenberg , Eric S. Lander , Katherine A. Siminovitch & Thomas J. Hudson

Linkage disequilibrium (LD) mapping provides a powerful method for fine-structure localization of rare disease genes, but has not yet been widely applied to common disease. We sought to design a systematic approach for LD mapping and apply it to the localization of a gene (IBD5) conferring susceptibility to Crohn disease.