A detailed knowledge of patterns of linkage disequilibrium in human populations is widely seen as a prerequisite for effective population-based disease gene mapping. New data suggest that linkage disequilibrium is highly structured into discrete blocks of sequence separated by hot spots of recombination.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
NtKRP, a kinesin-12 protein, regulates embryo/seed size and seed germination via involving in cell cycle progression at the G2/M transition
Scientific Reports Open Access 25 October 2016
-
Pharmacogenomic diversity in Singaporean populations and Europeans
The Pharmacogenomics Journal Open Access 27 May 2014
-
Most parsimonious haplotype allele sharing determination
BMC Bioinformatics Open Access 21 April 2009
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Clark, A.G. et al. Am. J. Hum. Genet. 63, 595–612 (1998).
Paulussen, A. et al. Pharmacogenetics 10, 415–424 (2000).
Finta, C. & Zaphiropoulous, P.G. Gene 260, 13–23 (2000).
Reich, D.E. et al. Nature 411, 199–204 (2001).
Daly, M.J. et al. Nature Genet. 29, 229–232 (2001).
Jeffreys, A.J. et al. Nature Genet. 29, 217–222 (2001).
Templeton, A.R. et al. Am. J. Hum. Genet. 66, 69–83 (2000).
Rioux, J.D. et al. Nature Genet. 29, 223–228 (2001).
Kuehl, P. et al. Nature Genet. 27, 383–391 (2001).
Johnson, G.C.L. et al. Nature Genet. 29, 233–237 (2001).
Stephens, J.C. et al. Science 20, 489–493 (2001).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Goldstein, D. Islands of linkage disequilibrium. Nat Genet 29, 109–111 (2001). https://doi.org/10.1038/ng1001-109
Issue Date:
DOI: https://doi.org/10.1038/ng1001-109
This article is cited by
-
NtKRP, a kinesin-12 protein, regulates embryo/seed size and seed germination via involving in cell cycle progression at the G2/M transition
Scientific Reports (2016)
-
Pharmacogenomic diversity in Singaporean populations and Europeans
The Pharmacogenomics Journal (2014)
-
BanI/D13S141/D13S175 Represents a Novel Informative Haplotype at the GJB2 Gene Region in the Iranian Population
Cellular and Molecular Neurobiology (2011)
-
Most parsimonious haplotype allele sharing determination
BMC Bioinformatics (2009)
-
Gene mapping in the wild with SNPs: guidelines and future directions
Genetica (2009)
