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Mitochondria in different tissues vary in number, morphology, ultrastructure, respiratory capacity and involvement in specific metabolic pathways. A comparison of the proteome of mitochondria from different tissues has identified the extent of the underlying variation in protein composition and how this may be determined by tissue-specific networks of coregulated genes.
In zebrafish, slow twitch muscle is specified from a somitic muscle precursor pool by local Hedgehog (Hh) signals. A new study identifies the transcription factor Blimp-1 as a key downstream mediator in this process.
In fly eye development, new experiments suggest that two distinct Pax genes control tissue growth and identity, respectively. Notably, these two functions may be encoded by distinct isoforms of the human gene PAX6
