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The flow of information in the brain is regulated over space and time. The authors show that mice can adaptively filter stimuli originating in the sensory cortex. The stimuli are gated by attractor dynamics in the frontal cortex, revealing a mechanism of gating of neural information.
Liu et al. present a flexible, insertable and transparent microelectrode (FITM) array termed Neuro-FITM. Multimodal recordings with Neuro-FITM reveal diverse and selective large-scale cortical activation patterns associated with hippocampal sharp-wave ripples.
Julian and Doeller show that trial-by-trial modulation of map-like representations in the human hippocampal–entorhinal system predicts contextual memory retrieval during virtual reality navigation independent of visual experience.
Xu et al. developed and characterized a new animal model of maternal immune activation based on a parasite mimetic. They show that immune and behavioral abnormalities in adult offspring are reversed by adoptive transfer of regulatory T cells.
Wingo et al. integrate depression GWAS results with human brain proteomes to perform proteome-wide association studies followed by Mendelian randomization. They identify 25 proteins as potential causal mediators of depression, of which 20 are new.
McNamee et al. develop a theory of entorhinal–hippocampal processing. Distributed entorhinal input drives hippocampal activity between distinct statistical and dynamical regimes of activity, thereby unifying several empirical observations.
Social interactions and relationships are often associated with a rewarding experience. Hu et al. show that mice display positive reinforcement of social interaction, and they identify an amygdala-to-hypothalamus circuit in mediating this social reward.
The authors develop a genetically encoded GPCR-based sensor to image serotonin dynamics in behaving animals with high specificity, sensitivity and spatiotemporal resolution.
During implicit learning, the authors find that sensory representations in mouse auditory cortex evolve over time, rotating into orthogonal memory representations. This allows short-term memories to avoid interference from new sensory inputs.
This study shows that hippocampus-dependent fear memories can be indirectly reactivated, captured and pharmacologically attenuated in rats. This reinforces the utility of imaginal reminders to target traumatic memories in humans.
AAV9-SMN is used to treat SMA. This study shows that AAV9-mediated SMN overexpression in mice causes late-onset motor dysfunction and synaptic and neuronal loss through protein aggregation, suggesting caution on the long-term safety of SMN gene therapy.
El-Gaby et al. combine multiunit recordings and optogenetic silencing in the mouse hippocampus and uncover a primary role for millisecond-timescale neural coactivity in encoding behavioral contingency information and supporting memory retrieval.
Although successful memory recall usually involves activation of broadly distributed networks, Vetere, Xia et al. show that the active disengagement of the anterodorsal thalamic nucleus is necessary for recall specifically at remote time-points.
Single-cell RNA-seq and CITE-seq were used to profile the glioblastoma immune landscape in humans and mice, revealing the diversity and dynamics of tumor macrophages as the disease progresses from initial diagnosis to recurrence.
Hennig et al. study how changes in internal state interact with learning in primates. They report stereotyped activity fluctuations in the motor cortex that reflect the animal’s level of engagement and predict how quickly the animals learned.
Combining virtual reality and large-scale calcium imaging, the authors demonstrate that hippocampal place cell remapping across contexts can be precisely predicted by the experience of the animal and approximates optimal probabilistic inference.
Yin et al. show that motor learning is delayed in mice with 16p11.2 deletion, associated with abnormal ensemble activity and delayed spine remodeling in motor cortex and reduced activity of of locus coeruleus noradrenergic neurons. The motor-related abnormalities were rescued by activation of ocus coeruleus noradrenergic neurons.
Eze et al. use single-cell sequencing and immunohistochemical validation to create an atlas of early human brain development. In the telencephalon, they discover a diversity of progenitor subtypes, including two that are enriched in humans.
Early life stress (ELS) promotes susceptibility to the effects of chronic stress in adulthood. Kronman et al. show that ELS alters H3K79me2 in D2 medium spiny neurons in the nucleus accumbens and that this underlies the susceptibility to the effects of subsequent stress.