Advance online publication
The latest research papers, published online ahead of print. These online versions are definitive and may be cited using the digital object identifier (DOI).
About advance online publicationBrief Communications
Thrombospondin 1 accelerates synaptogenesis in hippocampal neurons through neuroligin 1
Junyu Xu, Nan Xiao & Jun Xia
Published online: 15 November 2009 | doi:10.1038/nn.2459
In cultured rat hippocampal neurons, thrombospondin 1 hastened synapse formation via interaction with neuroligin 1.
Abstract - Thrombospondin 1 accelerates synaptogenesis in hippocampal neurons through neuroligin 1 | Full Text - Thrombospondin 1 accelerates synaptogenesis in hippocampal neurons through neuroligin 1 | PDF (794 KB) - Thrombospondin 1 accelerates synaptogenesis in hippocampal neurons through neuroligin 1 | Supplementary information
Dissociable cost and benefit encoding of future rewards by mesolimbic dopamine
Jerylin O Gan, Mark E Walton & Paul E M Phillips
Published online: 10 November 2009 | doi:10.1038/nn.2460
Cue-evoked activity of midbrain dopamine neurons is proposed to encode the magnitude, delay and uncertainty of predicted rewards. Here the authors report that this activity separates costs and benefits, as it does not encode the costs of the action required to obtain predicted rewards.
Abstract - Dissociable cost and benefit encoding of future rewards by mesolimbic dopamine | Full Text - Dissociable cost and benefit encoding of future rewards by mesolimbic dopamine | PDF (364 KB) - Dissociable cost and benefit encoding of future rewards by mesolimbic dopamine | Supplementary information
Article
Postnatal NMDA receptor ablation in corticolimbic interneurons confers schizophrenia-like phenotypes
Juan E Belforte, Veronika Zsiros, Elyse R Sklar, Zhihong Jiang, Gu Yu, Yuqing Li, Elizabeth M Quinlan & Kazu Nakazawa
Published online: 15 November 2009 | doi:10.1038/nn.2447
Nakazawa and colleagues describe a mouse strain in which the NR1 subunit of the NMDA receptor is selectively eliminated in cortical and hippocampal interneurons in early postnatal development. These mice have several behavioral deficits that are consistent with the theory that GABAergic dysfunction contributes to the pathology of several psychiatric disorders, including schizophrenia.
Abstract - Postnatal NMDA receptor ablation in corticolimbic interneurons confers schizophrenia-like phenotypes | Full Text - Postnatal NMDA receptor ablation in corticolimbic interneurons confers schizophrenia-like phenotypes | PDF (1,320 KB) - Postnatal NMDA receptor ablation in corticolimbic interneurons confers schizophrenia-like phenotypes | Supplementary information
Until print versions of AOP papers are published, they should be cited in the style "Author(s) Nature Neuroscience advance online publication, day month year (doi:10.1038/neuroXXXXX)". Once the print version (identical to the AOP) is published, it should be cited as follows: "Author(s) Nature Neuroscience volume, page (year); advance online publication, (doi:10.1038/neuroXXXXX)".
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