Advance online publication


The latest research papers, published online ahead of print. These online versions are definitive and may be cited using the digital object identifier (DOI).

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Brief Communications

Thrombospondin 1 accelerates synaptogenesis in hippocampal neurons through neuroligin 1

Junyu Xu, Nan Xiao & Jun Xia

Published online: 15 November 2009 | doi:10.1038/nn.2459

In cultured rat hippocampal neurons, thrombospondin 1 hastened synapse formation via interaction with neuroligin 1.


Dissociable cost and benefit encoding of future rewards by mesolimbic dopamine

Jerylin O Gan, Mark E Walton & Paul E M Phillips

Published online: 10 November 2009 | doi:10.1038/nn.2460

Cue-evoked activity of midbrain dopamine neurons is proposed to encode the magnitude, delay and uncertainty of predicted rewards. Here the authors report that this activity separates costs and benefits, as it does not encode the costs of the action required to obtain predicted rewards.


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Article

Postnatal NMDA receptor ablation in corticolimbic interneurons confers schizophrenia-like phenotypes

Juan E Belforte, Veronika Zsiros, Elyse R Sklar, Zhihong Jiang, Gu Yu, Yuqing Li, Elizabeth M Quinlan & Kazu Nakazawa

Published online: 15 November 2009 | doi:10.1038/nn.2447

Nakazawa and colleagues describe a mouse strain in which the NR1 subunit of the NMDA receptor is selectively eliminated in cortical and hippocampal interneurons in early postnatal development. These mice have several behavioral deficits that are consistent with the theory that GABAergic dysfunction contributes to the pathology of several psychiatric disorders, including schizophrenia.


Until print versions of AOP papers are published, they should be cited in the style "Author(s) Nature Neuroscience advance online publication, day month year (doi:10.1038/neuroXXXXX)". Once the print version (identical to the AOP) is published, it should be cited as follows: "Author(s) Nature Neuroscience volume, page (year); advance online publication, (doi:10.1038/neuroXXXXX)".

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