Advance online publication


The latest research papers, published online ahead of print. These online versions are definitive and may be cited using the digital object identifier (DOI).

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Brief Communication

Resolving single cone inputs to visual receptive fields

Lawrence C Sincich, Yuhua Zhang, Pavan Tiruveedhula, Jonathan C Horton & Austin Roorda

Published online: 28 June 2009 | doi:10.1038/nn.2352

Current techniques are insufficient for resolving the contribution of single photoreceptors to the responses of visually responsive neurons in the brain. Here, the authors employ a new technique, which utilizes adaptive optics, to show that LGN neurons respond reliably to the stimulation of a single cone.


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Articles

A discrete alcohol pocket involved in GIRK channel activation

Prafulla Aryal, Hay Dvir, Senyon Choe & Paul A Slesinger

Published online: 28 June 2009 | doi:10.1038/nn.2358

Ethanol activates G protein-gated inwardly rectifying K+ (GIRK) channels, but it is unclear how. This study identifies an alcohol-binding pocket located in the cytoplasmic domains of GIRK2. A leucine residue in this pocket was crucial for GIRK2 activation by alcohols, but was not involved in the alcohol inhibition of related, but constitutively active, K+ channels.


A trophic role for Wnt-Ror kinase signaling during developmental pruning in Caenorhabditis elegans

Yu Hayashi, Takaaki Hirotsu, Ryo Iwata, Eriko Kage-Nakadai, Hirofumi Kunitomo, Takeshi Ishihara, Yuichi Iino & Takeo Kubo

Published online: 28 June 2009 | doi:10.1038/nn.2347

Some neurites in developing C. elegans interneurons are eventually pruned. Which exact neurites are subject to pruning appears to be random, suggesting an ongoing local competition between pro- and anti-pruning signals. Hayashi and colleagues show that Wnt signaling through the transmembrane receptor kinase CAM-1/Ror protects developing neurites from being pruned.


Until print versions of AOP papers are published, they should be cited in the style "Author(s) Nature Neuroscience advance online publication, day month year (doi:10.1038/neuroXXXXX)". Once the print version (identical to the AOP) is published, it should be cited as follows: "Author(s) Nature Neuroscience volume, page (year); advance online publication, (doi:10.1038/neuroXXXXX)".

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