Advance online publication
The latest research papers, published online ahead of print. These online versions are definitive and may be cited using the digital object identifier (DOI).
About advance online publicationBrief Communication
Resolving single cone inputs to visual receptive fields
Lawrence C Sincich, Yuhua Zhang, Pavan Tiruveedhula, Jonathan C Horton & Austin Roorda
Published online: 28 June 2009 | doi:10.1038/nn.2352
Current techniques are insufficient for resolving the contribution of single photoreceptors to the responses of visually responsive neurons in the brain. Here, the authors employ a new technique, which utilizes adaptive optics, to show that LGN neurons respond reliably to the stimulation of a single cone.
Abstract - | Full Text - Resolving single cone inputs to visual receptive fields | PDF (313 KB) - Resolving single cone inputs to visual receptive fields | Supplementary information
Articles
A discrete alcohol pocket involved in GIRK channel activation
Prafulla Aryal, Hay Dvir, Senyon Choe & Paul A Slesinger
Published online: 28 June 2009 | doi:10.1038/nn.2358
Ethanol activates G protein-gated inwardly rectifying K+ (GIRK) channels, but it is unclear how. This study identifies an alcohol-binding pocket located in the cytoplasmic domains of GIRK2. A leucine residue in this pocket was crucial for GIRK2 activation by alcohols, but was not involved in the alcohol inhibition of related, but constitutively active, K+ channels.
Abstract - | Full Text - A discrete alcohol pocket involved in GIRK channel activation | PDF (691 KB) - A discrete alcohol pocket involved in GIRK channel activation | Supplementary information
A trophic role for Wnt-Ror kinase signaling during developmental pruning in Caenorhabditis elegans
Yu Hayashi, Takaaki Hirotsu, Ryo Iwata, Eriko Kage-Nakadai, Hirofumi Kunitomo, Takeshi Ishihara, Yuichi Iino & Takeo Kubo
Published online: 28 June 2009 | doi:10.1038/nn.2347
Some neurites in developing C. elegans interneurons are eventually pruned. Which exact neurites are subject to pruning appears to be random, suggesting an ongoing local competition between pro- and anti-pruning signals. Hayashi and colleagues show that Wnt signaling through the transmembrane receptor kinase CAM-1/Ror protects developing neurites from being pruned.
Abstract - | Full Text - A trophic role for Wnt-Ror kinase signaling during developmental pruning in Caenorhabditis elegans | PDF (527 KB) - A trophic role for Wnt-Ror kinase signaling during developmental pruning in Caenorhabditis elegans | Supplementary information
Until print versions of AOP papers are published, they should be cited in the style "Author(s) Nature Neuroscience advance online publication, day month year (doi:10.1038/neuroXXXXX)". Once the print version (identical to the AOP) is published, it should be cited as follows: "Author(s) Nature Neuroscience volume, page (year); advance online publication, (doi:10.1038/neuroXXXXX)".
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