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  • Cortical excitatory neurons are narrowly tuned to sensory inputs, but the tuning of interneurons is perceived as broad and irregular. Duszkiewicz et al. demonstrate that interneuron tuning is structured and reflects the sum of local excitatory inputs.

    • Adrian J. Duszkiewicz
    • Pierre Orhan
    • Adrien Peyrache
    ArticleOpen Access
  • As Nature Neuroscience celebrates its 25th anniversary, we are having conversations with both established leaders in the field and those earlier in their careers to discuss how the field has evolved, and where it is heading. This month, we are talking to Igor Adameyko (Department Chair at the Center for Brain Research of the Medical University of Vienna, Austria, and a group leader at the Karolinska Institutet, Sweden), a developmental biologist by training with research interests ranging from neural crest cell fate to aquatic life and a champion of a positive research culture.

    • Elisa Floriddia
    Q&A
  • This paper identifies the evolutionarily conserved liprin-α protein family as key mediators of presynaptic assembly in human neurons. Their recruitment to sites formed by contacting neurons is the critical initial step that triggers presynaptic differentiation.

    • Berta Marcó de la Cruz
    • Joaquín Campos
    • Fredrik H. Sterky
    ArticleOpen Access
  • Cold sensor identities in peripheral somatosensory neurons remain obscure. We show that GluK2, a kainate-type glutamate-sensing chemoreceptor that mediates synaptic transmission in the brain, mediates the sensing of cold but not cool temperatures in mouse dorsal root ganglia neurons in the periphery. Thus, we identify GluK2 as a cold-sensing thermoreceptor.

    Research Briefing
  • The identity of receptors sensing cold temperatures in peripheral somatosensory neurons remains obscure. Cai et al. report that GluK2, a kainate receptor mediating synaptic transmission in the brain, is co-opted as a cold sensor in the periphery.

    • Wei Cai
    • Wenwen Zhang
    • X. Z. Shawn Xu
    Article
  • Astrocytes have important roles in disease and are difficult to modulate, owing to a paucity of known targets. Clayton et al. develop a screening platform to unbiasedly identify modulators of astrocyte reactivity. They discover that HDAC3 inhibitors regulate astrocyte transitions into their reactive phenotype in vitro and in vivo.

    • Francesco Limone
    • Shane Liddelow
    News & Views
  • Brain connections modulated by 534 deep-brain-stimulation electrodes revealed a gradient of circuits involved in dystonia, Parkinson’s disease, Tourette’s syndrome and obsessive-compulsive disorder. Together, these circuits begin to describe the human ‘dysfunctome’, a library of dysfunctional circuits that lead to various brain disorders.

    Research Briefing
  • Long COVID has remained an on-going public health issue in the years following the global pandemic. Here, we report blood–brain barrier disruption in patients with acute SARS-CoV-2 infection and brain fog, and patients presenting with long COVID, brain fog and cognitive decline, compared to those with long COVID without any neurological symptoms.

    Research Briefing
  • Hollunder et al. identify networks where deep brain stimulation reduces symptoms for Parkinson’s disease, Tourette’s syndrome, dystonia and obsessive-compulsive disorder. This revealed a fronto-rostral topography that segregates the frontal cortex.

    • Barbara Hollunder
    • Jill L. Ostrem
    • Andreas Horn
    ArticleOpen Access