Nature Neuroscience 9, 868 - 869 (2006)
Published online: 28 May 2006; | doi:10.1038/nn1713
Cocaine self-administration selectively abolishes LTD in the core of the nucleus accumbensMiquel Martin1, 4, Billy T Chen1, 4, F Woodward Hopf1, M Scott Bowers1
& Antonello Bonci1, 2, 31
Ernest Gallo Clinic and Research Center, 5858 Horton Street, Suite 200, Emeryville, California 94608, USA. 2
Department of Neurology, University of California San Francisco, San Francisco, California 94608, USA. 3
Wheeler Center for the Neurobiology of Drug Addiction, University of California San Francisco, San Francisco, California 94608, USA. 4
These authors contributed equally to this work.
Correspondence should be addressed to Antonello Bonci bonci@itsa.ucsf.edu The core and shell of the nucleus accumbens have critical, differential roles in drug-dependent behaviors. Here we show that operant cocaine self-administration inhibits long-term depression (LTD) in both structures after 1 d of abstinence. However, after 21 d of abstinence, LTD was abolished exclusively in the nucleus accumbens core of cocaine self-administering rats, suggesting that voluntary cocaine self-administration induced long-lasting neuroadaptations in the core that could underlie drug-seeking behavior and relapse.
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