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How amyloid, sleep and memory connect

Nature Neuroscience volume 18, pages 933–934 (2015)Cite this article

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In a bidirectional relationship, the sleep/wake cycle regulates amyloid-β (Aβ) levels and Aβ accumulation then disrupts sleep. A quantitative three-way model now suggests that Aβ impairs memory via its effect on sleep.

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Figure 1: Models for the relationship among amyloid, sleep and memory.

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Authors and Affiliations

  1. Brendan P. Lucey and David M. Holtzman are in the Department of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, Washington University, St. Louis, Missouri, USA.,

    Brendan P Lucey & David M Holtzman

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  1. Brendan P Lucey
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  2. David M Holtzman
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Corresponding author

Correspondence to David M Holtzman.

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Competing interests

D.M.H. is a co-founder of C2N Diagnostics LLC and is on the scientific advisory boards of, or consults for, AstraZeneca, Genentech, Eli Lilly, Neurophage and C2N Diagnostics. Washington University receives research grants to the laboratory of D.M.H. from Cure Alzheimer's Fund, the JPB Foundation, Tau Consortium, Eli Lilly and C2N Diagnostics.

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Lucey, B., Holtzman, D. How amyloid, sleep and memory connect. Nat Neurosci 18, 933–934 (2015). https://doi.org/10.1038/nn.4048

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