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Neighborly synapses help each other out

Cortical circuits are shaped by sensory experience. These changes have now been visualized with single-synapse resolution in vivo, revealing clustered potentiation along stretches of dendrite.

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Figure 1: Repetitive stimulation of a single whisker triggered enhanced surface expression of AMPA receptors in somatosensory cortex.

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References

  1. Margolis, D.J. et al. Nat. Neurosci. 15, 1539–1546 (2012).

    Article  CAS  Google Scholar 

  2. Zhang, Y., Cudmore, R.H., Lin, D.T., Linden, D.J. & Huganir, R.L. Nat. Neurosci. 18, 402–407 (2015).

    Article  CAS  Google Scholar 

  3. Ashby, M.C. et al. J. Neurosci. 24, 5172–5176 (2004).

    Article  CAS  Google Scholar 

  4. Shi, S.H. et al. Science 284, 1811–1816 (1999).

    Article  CAS  Google Scholar 

  5. Makino, H. & Malinow, R. Neuron 72, 1001–1011 (2011).

    Article  CAS  Google Scholar 

  6. Gambino, F. et al. Nature 515, 116–119 (2014).

    Article  CAS  Google Scholar 

  7. Takahashi, N. et al. Science 335, 353–356 (2012).

    Article  CAS  Google Scholar 

  8. Harvey, C.D. & Svoboda, K. Nature 450, 1195–1200 (2007).

    Article  CAS  Google Scholar 

  9. Iannella, N.L., Launey, T. & Tanaka, S. Front. Comput. Neurosci. 4, 21 (2010).

    PubMed  PubMed Central  Google Scholar 

  10. Branco, T. & Häusser, M. Curr. Opin. Neurobiol. 20, 494–502 (2010).

    Article  CAS  Google Scholar 

  11. Holtmaat, A., Wilbrecht, L., Knott, G.W., Welker, E. & Svoboda, K. Nature 441, 979–983 (2006).

    Article  CAS  Google Scholar 

  12. Hofer, S.B., Mrsic-Flogel, T.D., Bonhoeffer, T. & Hubener, M. Nature 457, 313–317 (2009).

    Article  CAS  Google Scholar 

  13. Wiegert, J.S. & Oertner, T.G. Proc. Natl. Acad. Sci. USA 110, E4510–E4519 (2013).

    Article  CAS  Google Scholar 

  14. Hsu, P.D., Lander, E.S. & Zhang, F. Cell 157, 1262–1278 (2014).

    Article  CAS  Google Scholar 

  15. Lashley, K.S. Science 73, 245–254 (1931).

    Article  CAS  Google Scholar 

Download references

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Correspondence to Thomas G Oertner.

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Wiegert, J., Oertner, T. Neighborly synapses help each other out. Nat Neurosci 18, 326–327 (2015). https://doi.org/10.1038/nn.3955

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